Hippocampal CA1 represents action and reward events instantly compared to the superficial and deep layers of the lateral entorhinal cortex
Hippocampal CA1 represents action and reward events instantly compared to the superficial and deep layers of the lateral entorhinal cortex
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与外侧内嗅皮层的浅层和深层相比，海马 CA1 立即代表行动和奖励事件
DOI：
10.1101/2022.03.31.485431
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Isomura Yoshikazu
中科院分区：
文献类型：
--
作者：
Soma Shogo;Ohara Shinya;Nonomura Satoshi;Yoshida Junichi;Suematsu Naofumi;Pastalkova Eva;Sakai Yutaka;Tsutsui Ken-Ichiro;Isomura Yoshikazu
内嗅皮层(EC)是连接海马区和新皮质的主要界面。EC在学习和记忆中起着至关重要的作用。我们研究了头部固定大鼠在操作学习过程中海马内嗅回路中行为事件的神经元表征。CA1和外侧内嗅皮层(LEC)神经元在学习后都会发展与任务相关的活动。在不同的任务相关活动中，我们比较了代表行动和奖励的瞬时峰值活动，发现CA1和LEC在行为事件表征的时间上存在显著差异。CA1代表接近实时的行为和奖励事件，而LEC的表层和深层都显示出这些事件的延迟呈现。我们的结果表明，CA1和LEC神经元以不同于解剖定义的海马内嗅路的顺序处理信息的亚群存在。
The entorhinal cortex (EC) is the main interface between the hippocampus and the neocortex. The EC plays a critical role in learning and memory. We investigated the neuronal representation of behavioral events during operant learning in the hippocampal-entorhinal circuit of head-fixed rats. Both CA1 and lateral entorhinal cortex (LEC) neurons develop task-related activities after learning. Among diverse task-related activities, we compared the transient peak activities that represent action and reward and found a distinct difference in the timing of behavioral event representation between CA1 and LEC. CA1 represents action and reward events in close to real-time, whereas both the superficial and deep layers of the LEC showed delayed representation of those events. Our results suggest that subpopulations exist within which CA1 and LEC neurons process the information in a different order from the anatomically defined hippocampal-entorhinal circuit.
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影响因子：
2.5
作者：
Biella, G;De Curtis, M
通讯作者：
De Curtis, M
神经元和网络
DOI：
--
发表时间：
2001
期刊：
影响因子：
--
作者：
Dowling;M. Fisher
通讯作者：
M. Fisher
影响因子：
2.5
作者：
Deshmukh, Sachin S.;Yoganarasimha, D.;Knierim, James J.
通讯作者：
Knierim, James J.
影响因子：
3
作者：
Deshmukh SS;Knierim JJ
通讯作者：
Knierim JJ
神经元的逆向激活作为中枢神经系统研究的分析工具
影响因子：
3
作者：
J. Lipski
通讯作者：
J. Lipski