Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones
Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones
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DOI：
10.1002/anie.201700231
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发表时间：
2017-05-02
影响因子：
16.6
通讯作者：
Soos, Tibor
中科院分区：
文献类型：
--
作者：
Bakos, Maria;Gyomore, Adam;Soos, Tibor
在这里，我们报告了单个受抑的刘易斯对（FLP）催化剂可以促进醛和酮的还原醚化。该反应不需要外源酸催化剂，但FLP对H-2、R-OH或H2O的组合作用以可逆的开启方式产生所需的布朗斯台德酸。该方法不仅是一种互补的无金属还原醚化反应，而且是一个利基程序的醚，将是合成不便，甚至难以通过替代的合成方案访问。
Herein we report that a single frustrated Lewis pair (FLP) catalyst can promote the reductive etherification of aldehydes and ketones. The reaction does not require an exogenous acid catalyst, but the combined action of FLP on H-2, R-OH or H2O generates the required BrOnsted acid in a reversible, turn on manner. The method is not only a complementary metal-free reductive etherification, but also a niche procedure for ethers that would be either synthetically inconvenient or even intractable to access by alternative synthetic protocols.