Cortical, thalamic, and hypothalamic responses to cooling and warming the skin in awake humans: A positron-emission tomography study
Cortical, thalamic, and hypothalamic responses to cooling and warming the skin in awake humans: A positron-emission tomography study
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DOI：
10.1073/pnas.0409753102
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发表时间：
2005-04-05
影响因子：
11.1
通讯作者：
Fox, PT
中科院分区：
文献类型：
--
作者：
Egan, GF;Johnson, J;Fox, PT
体温调节机制非常有效，确保在生理条件下人体核心内的温度变化最小。不同的传入和传出神经通路有助于监测核心和皮肤温度、产生热量以及控制与外部环境的热交换。我们已经调查了皮质，丘脑和下丘脑的反应，冷却和变暖，使用正电子发射断层扫描激活成像的主题穿着水灌注的西装，使他们的皮肤表面温度的快速变化。人类大脑中对皮肤温度变化做出反应的区域已经在体感皮层、丘脑、前扣带回、丘脑和下丘脑中被确定，有证据表明下丘脑反应编码温度变化的方向。我们的结论是，从皮肤中的温度传感器提供关键的传入信息的大脑的信号与中央温度传感器的信号相结合，从而导致温度调节反应，保持核心温度在一个非常窄的范围内。
Thermoregulatory mechanisms are remarkably efficient, ensuring minimal temperature variation within the core of the human body under physiological conditions. Diverse afferent and efferent neural pathways contribute to the monitoring of core and skin temperature, generation of heat, and control of thermal exchange with the external environment. We have investigated the cortical, thalamic, and hypothalamic responses to cooling and warming by using positron-emission tomography activation imaging of subjects clad in a water-perfused suit, which enabled rapid change of their skin-surface temperature. Human brain regions that respond to changes in skin temperature have been identified in the somatosensory cortex, insula, anterior cingulate, thalamus, and hypothalamus, with evidence that the hypothalamic response codes for the direction of temperature change. We conclude that signals from thermosensors in the skin providing crucial afferent information to the brain are integrated with signals from central thermosensors, resulting in thermoregulatory responses that maintain core temperature within a remarkably narrow range.