EFFECTS OF D-AMPHETAMINE AND L-AMPHETAMINE ON FOOD-INTAKE - EVIDENCE FOR A DOPAMINERGIC SUBSTRATE
EFFECTS OF D-AMPHETAMINE AND L-AMPHETAMINE ON FOOD-INTAKE - EVIDENCE FOR A DOPAMINERGIC SUBSTRATE
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DOI：
10.1016/0091-3057(87)90189-4
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发表时间：
1987-08-01
影响因子：
3.6
通讯作者：
VACCARINO, FJ
中科院分区：
文献类型：
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作者：
EVANS, KR;VACCARINO, FJ
本实验研究了D-和1-安非他明对自由喂养大鼠摄入糖、加糖大鼠饲料和不加糖大鼠饲料的影响。向大鼠IP注射4种剂量的d-或l-苯丙胺（0.0、0.125、0.50和2.00 mg/kg）。无论药物条件如何，发现动物更喜欢糖而不是加糖或不加糖的食物，d-苯丙胺在0.125和0.50 mg/kg剂量下显著增加摄食量，但在2.00 mg/kg剂量下则没有。1-安非他明在任何剂量下均无显著影响。此外，d-安非他明显着增加糖的摄入量，但不加糖或不加糖的食物。由于d-和1-安非他明是等效的释放去甲肾上腺素，而d-安非他明是2至5倍更有效地释放多巴胺，结果表明，d-安非他明诱导的进食与多巴胺能底物的激活。
The present experiment examined the effects of d- and 1-amphetamine on the intake of sugar, sweetened rat chow and unsweetened rat chow in free feeding rats. Rats were injected IP with 4 doses of d- or l-amphetamine (0.0, 0.125, 0.50 and 2.00 mg/kg). Regardless of drug condition, animals were found to prefer sugar over sweetened or unsweetened chow, d-Amphetamine significantly increased food intake at 0.125 and 0.50 mg/kg doses but not at 2.00 mg/kg. 1-Amphetamine had no significant effects at any dose. Further, d-amphetamine significantly increased sugar intake but not sweetened or unsweetened chow. Since d- and 1-amphetamine are equipotent at releasing noradrenaline, while d-amphetamine is 2 to 5 times more potent at releasing dopamine, the results suggest that d-amphetamine-induced feeding is associated with activation of a dopaminergic substrate.