GBR-12909-induced self-injurious behavior: role of dopamine.
GBR-12909-induced self-injurious behavior: role of dopamine.
复制标题
GBR-12909 诱导的自残行为：多巴胺的作用。
DOI：
10.1016/0006-8993(95)00604-o
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Sivam,SP
中科院分区：
文献类型：
--
作者：
Sivam,SP
重复施用GBR（10或20 mg/kg/天，i. p.，持续4天）诱导了由身体区域、爪和尾部损伤组成的自伤行为（SIB）发生率的剂量和时间相关性增加。治疗方案降低纹状体DA和DOPAC水平。去多巴胺神经6-羟多巴胺（6-OHDA）或D1 DA拮抗剂SCH-23390或D2 DA拮抗剂spiperone可阻断GBR诱导的SIB。雄性大鼠对SIB发生率的敏感性低于雌性大鼠。总之，研究表明，重复给药GBR诱导SIB，这是依赖于黑质纹状体多巴胺能系统的完整性和D1和/或D2 DA受体的存在。
A regimen of repeated administration of GBR (10 or 20 mg/kg/day, i.p., for 4 days) to female Sprague-Dawley rats induced a dose-and time-related increase in the incidence of self-injurious behavior (SIB) that consisted of injury to body areas, paws and tail. The treatment regimen decreased striatal DA and DOPAC levels. Dopaminergic denervation with 6-hydroxydopamine (6-OHDA) or D1 DA antagonist, SCH-23390 or D2 DA antagonist, spiperone, blocked the GBR-induced SIB. Male rats were less sensitive than female rats to exhibit a comparable incidence of SIB. Taken together, the study reveals that repeated administration of GBR induces SIB that is dependent on the integrity of nigrostriatal dopaminergic system and the presence of D1 and/or D2 DA receptors.