Potential triggers of MS.
Potential triggers of MS.
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DOI：
10.1007/400_2008_12
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发表时间：
2010
影响因子：
--
通讯作者：
Fujinami, Robert S
中科院分区：
文献类型：
--
作者：
Libbey, Jane E;Fujinami, Robert S
MS是一种免疫介导的中枢神经系统（CNS）疾病，其特征在于脱髓鞘、轴突损伤和神经功能障碍。这种中枢神经系统疾病的主要原因仍然难以捉摸。在这里，我们将解决我们目前的理解的作用，病毒作为潜在的环境触发MS。病毒感染可以采取行动外周（CNS外）或CNS内。将讨论动物和人类中病毒感染与脱髓鞘疾病的关联，以及外周感染Torque Teno病毒、CNS外和/或CNS内感染Epstein-Barr病毒和CNS内感染人疱疹病毒6对MS的潜在贡献。Theiler小鼠脑脊髓炎病毒感染易感品系小鼠是CNS病毒感染作为脱髓鞘先决条件的一个例子。最后，需要多个病毒感染的命题，首先引发免疫系统，然后触发疾病，作为一个模型，在CNS外的感染导致CNS内的炎症变化，为MS样疾病的发展进行了探讨。
MS is an immune mediated disease of the central nervous system (CNS) characterized by demyelination, axonal damage and neurologic disability. The primary cause of this CNS disease remains elusive. Here we will address our current understanding of the role of viruses as potential environmental triggers for MS. Virus infections can act peripherally (outside the CNS) or within the CNS. The association of viral infections with demyelinating disease, in both animals and humans, will be discussed, as will the potential contributions of peripheral infection with Torque Teno virus, infection outside of and/or within the CNS with Epstein–Barr virus and infection within the CNS with Human Herpesvirus 6 to MS. An experimental animal model, Theiler’s murine encephalomyelitis virus infection of susceptible strains of mice is an example of viral infections of the CNS as a prerequisite for demyelination. Finally, the proposition that multiple virus infections are required, which first prime the immune system and then trigger the disease, as a model where infections outside of the CNS lead to inflammatory changes within the CNS, for the development of a MS-like disease is explored.