Pathogenicity of two Chinese Seneca Valley virus (SVV) strains in pigs
Pathogenicity of two Chinese Seneca Valley virus (SVV) strains in pigs
复制标题
两种中国塞内卡谷病毒（SVV）毒株对猪的致病性
DOI：
10.1016/j.micpath.2019.103695
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发表时间：
2019-11-01
影响因子：
3.8
通讯作者：
Chen, Zhenhai
中科院分区：
文献类型：
--
作者：
Chen, Lulu;Zhang, Jialong;Chen, Zhenhai
Seneca Valley病毒（SVV）已被确定为SVV相关水疱病（SAVD）的病原体。为了研究中国新分离的两株SW菌株（GD-S5/2018和GD 04/2017）的致病性，进行了猪的实验感染。在猪实验中，两种SVV毒株均成功感染所有动物，表现为病毒脱落和强大的保护性抗体应答。SVV GD-S5/2018感染导致特征性临床体征以及舌头和牙龈上的溃疡性病变。然而，SVV GD 04/2017在实验期间未引起猪的任何临床症状，但出现抑郁。综上所述，这些结果表明SVV GD-S5/2018是猪的强毒株，而SVV GD 04/2017几乎无毒力。建立的SVV感染动物模型将用于研究SVV的免疫和发病机制，并开发疫苗和抗病毒药。
Seneca Valley virus (SVV) has been identified as the causative agent of SVV-associated vesicular disease (SAVD). To investigate the pathogenicity of two newly isolated SW strains (GD-S5/2018 and GD04/2017) in China, experimental infections of pigs were performed. In pig experiments, both SVV strains successfully infected all animals, evidenced by presence of virus shedding and robust protective antibody responses. SVV GD-S5/2018 infection resulted in characteristic clinical signs, and ulcerative lesions on the tongue and gums. However, SVV GD04/2017 did not cause any clinical symptoms except depression in pigs during the experiment. Taken together, these results demonstrate that SVV GD-S5/2018 is a virulent strain for pigs, whereas SVV GD04/2017 is nearly avirulent. The established animal models for SVV infection will be utilized to dissect the immunity and pathogenesis, and develop vaccines and antivirals.