Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia.
Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia.
复制标题
针对精神分裂症前代和早期阶段脑可塑性的认知干预措施。
DOI：
10.1146/annurev-clinpsy-032511-143134
复制
发表时间：
2013
影响因子：
18.4
通讯作者：
Vinogradov S
中科院分区：
文献类型：
--
作者：
Fisher M;Loewy R;Hardy K;Schlosser D;Vinogradov S
Several important paradigm shifts have occurred in the field of schizophrenia treatment, including an increased focus on early detection, the development of preemptive interventions, and the view of schizophrenia as a neurodevelopmental disease characterized by decreased efficiency and abnormal connectivity in cortical and subcortical neural networks. In this review article, we will briefly describe some of the neural impairments that contribute to the development of schizophrenia, with an emphasis on the impact of stress and trauma on cognitively vulnerable neural systems. We will then present current data on two behavioral interventions that target these critical risk factors and that aim to preempt the onset of schizophrenia in vulnerable individuals or improve the clinical course in recent onset schizophrenia: cognitive therapy and computerized cognitive training.
