New trends in bioactive scaffolds: The importance of nanostructure
New trends in bioactive scaffolds: The importance of nanostructure
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DOI：
10.1016/j.jeurceramsoc.2008.08.003
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发表时间：
2009-04-01
影响因子：
5.7
通讯作者：
Jones, Julian R.
中科院分区：
文献类型：
--
作者：
Jones, Julian R.
理想的支架有许多标准，可以刺激身体的修复机制，使患病或受损的骨骼再生到原始的健康状态。这些包括具有足够大和开放的孔隙网络，以供细胞和血管渗透，并能够与骨骼结合。溶胶-凝胶法制备的生物活性玻璃具有纳米孔隙率，可以控制降解速率。它们可以发泡以产生模拟松质骨宏观结构的支架。具有优化的纳米孔隙率的生物活性玻璃泡沫在压缩中是强的;然而，当在张力下加载时，它们具有低的韧性和孔强度。因此，理想的支架将具有玻璃的所有性质，并具有增强的韧性。这只能通过创造新的纳米复合材料来实现。可再吸收聚合物必须与纳米级的二氧化硅基无机网络相互作用，以保持生物活性和受控的再吸收。这是一个复杂的问题，但可能是支架发展的未来。(C)2008爱思唯尔有限公司保留所有权利。
There are many criteria for an ideal scaffold that will stimulate the body's repair mechanisms to regenerate diseased or damaged bone to its original healthy state. These include having a pore network large and open enough for cells and blood vessels to penetrate and the ability to bond to bone. Sol-gel derived bioactive glasses have a nanoporosity that can control degradation rate. They can be foamed to produce scaffolds that mimic cancellous bone macrostructure. Bioactive glass foams with optimised nanoporosity are strong in compression; however, they have low toughness and pore strength when loaded in tension. Therefore an ideal scaffold would have all the properties of the glasses with enhanced toughness. This can only be achieved by creating new nanoscale composites. Resorbable polymers must interact with the silica based inorganic network at the nanoscale to maintain bioactivity and controlled resorption. This is a complex problem but may be the future of scaffold development. (C) 2008 Elsevier Ltd. All rights reserved.