DCDB: Drug combination database
DCDB: Drug combination database
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DCDB：药物组合数据库
DOI：
10.1093/bioinformatics/btp697
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发表时间：
2010-02-15
期刊：
影响因子：
5.8
通讯作者：
Chen, Xin
中科院分区：
文献类型：
--
作者：
Liu, Yanbin;Hu, Bin;Chen, Xin
摘要
药学的快速发展引起了人们对联合治疗的兴趣，以获得更好的临床疗效和安全性，特别是在复杂和难治性疾病的情况下。正在积极开发多组分药物研究的创新实验技术和理论框架。在这项工作中，我们提出了药物组合数据库，旨在促进对已知药物组合的分析，总结有益药物相互作用的模式，并为此类药物相互作用的理论建模和模拟提供基础。它的当前版本(1.0)从6000篇参考文献中收集了499个批准或研究的药物组合，包括40个不成功的药物组合，涉及485个单独的药物。
SUMMARY
Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug research. In this work, we present the Drug Combination Database, with aims to facilitate analyses of known drug combinations, to summarize patterns of beneficial drug interactions, and to provide a basis for theoretical modeling and simulation of such drug interactions. Its current version (1.0) collected 499 approved or investigational drug combinations, including 40 unsuccessful drug combinations, involving 485 individual drugs, from >6000 references.