Mixing and Fluid Dynamics Effects in Particle Precipitation Processes
Mixing and Fluid Dynamics Effects in Particle Precipitation Processes
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DOI：
10.14356/kona.2016021
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发表时间：
2016
影响因子：
4.1
通讯作者：
J. Bałdyga
中科院分区：
文献类型：
--
作者：
J. Bałdyga
沉淀被定义为在高过饱和条件下从液体溶液中快速形成适度可溶的结晶或无定形固体颗粒。它涉及同时和快速发生的初级成核和生长的颗粒连同次级过程，如聚集和破碎。它示出了流体流动和混合的影响如何影响形成整个降水过程的子过程。给出了反应沉淀法和超临界流体反溶剂沉淀法的实例。基本的子过程形成的整体沉淀过程（即宏观，介观，微观混合，化学反应，成核和颗粒的生长，聚集和破碎）的特点是由相关的时间常数和应用程序的时间常数在建模和放大的沉淀过程。湍流对颗粒形成的影响采用机械模型、CFD和粒子数平衡（包括矩量法和矩量求积法）进行模拟。模型的结果与实验数据进行了比较。最后，它示出在实际应用的背景下，本文中讨论的方法在何种程度上可以应用于“设计”粒子。
Precipitation defined as the rapid formation of moderately soluble crystalline or amorphous solid particles from a liquid solution under high supersaturation conditions is considered. It involves the simultaneous and fast occurrence of primary nucleation and growth of particles together with the secondary processes such as aggregation and breakage. It is shown how the effects of fluid flow and mixing affect the subprocesses forming the overall precipitation process. Examples are presented for reactive precipitation and antisolvent precipitation with supercritical fluids applied as the antisolvents. The elementary subprocesses forming the overall precipitation process (i.e. macro-, meso-, micromixing, chemical reaction, nucleation and growth of particles, aggregation and breakage) are characterized by the related time constants and the application of time constants in the modeling and scale-up of precipitation processes is presented. The effects of turbulence on particle formation are simulated using mechanistic models, CFD and population balances (including the method of moments and the quadrature method of moments). The results of modeling are compared with experimental data. Finally, it is shown in the context of practical applications to what extent the approaches discussed in this paper can be applied to “design” particles.