Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: A resting-state EEG and TMS-EEG study
Modulation of cortical responses by transcranial direct current stimulation of dorsolateral prefrontal cortex: A resting-state EEG and TMS-EEG study
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DOI：
10.1016/j.brs.2018.06.004
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发表时间：
2018-09-01
影响因子：
7.7
通讯作者：
Ziemann, Ulf
中科院分区：
文献类型：
--
作者：
Gordon, Pedro Caldana;Zrenner, Christoph;Ziemann, Ulf
背景资料：经颅直流电刺激（tDCS）是一种非侵入性脑刺激技术，具有成本效益的治疗性神经调节的潜力。虽然通过刺激背外侧前额叶皮层（DLPFC）发现了积极的治疗效果，但很少有研究探讨DLPFC-tDCS的生理效应。目的：通过静息态脑电图（rs-EEG）和经颅磁刺激（TMS）诱发/诱导的EEG反应，研究tDCS与应用于左侧DLPFC的不同参数设置对皮质反应的影响。22例健康受试者在双盲随机交叉设计中接受了5次不同tDCS参数设置的tDCS治疗（1：1.5 mA，阳极左DLPFC，阴极右DLPFC; 2：1.5 mA，阴极左DLPFC，阳极右DLPFC; 3：0.5 mA，阳极左DLPFC，阴极右DLPFC; 4：1.5 mA，阳极左DLPFC，阴极左三角肌; 5：假刺激）。结果：在tDCS条件下，Rs-EEG功率谱分析显示，刺激前和刺激后的Rs-EEG功率谱无明显差异。1.5mA左侧DLPFC阳极tDCS后，顶叶皮层的TMS-EEG诱发电位振幅降低，使用左侧DLPFC阳极tDCS的所有条件后，TMS诱导的伽马和θ振荡均降低。左DLPFC阴极tDCS未导致显著变化。没有干预后的变化是不同的条件下，包括sham.Conclusions比较的效果时，我们的研究没有提供证据表明，一个单一的tDCS会话结果在rs-EEG的显着变化，使用当前的刺激参数。在阳极1.5 mA tDCS干预后，观察到对TMS脉冲的EEG反应发生显著变化，尽管这些变化在组比较中不具有统计学显著性。(c)2018爱思唯尔公司All rights reserved.
Background: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique with potential for cost-effective therapeutic neuromodulation. Although positive therapeutic effects were found by stimulating the dorsolateral prefrontal cortex (DLPFC), few studies have investigated physiological effects of DLPFC-tDCS.Objectives: To investigate effects of tDCS with different parameter settings applied to the left DLPFC on cortical responses, measured by resting-state electroencephalography (rs-EEG) and transcranial magnetic stimulation (TMS)-evoked/induced EEG responses.Methods: 22 healthy subjects underwent 5 tDCS sessions with different tDCS parameter settings in a double-blinded randomized crossover design (1: 1.5 mA, anode left-DLPFC, cathode right-DLPFC; 2: 1.5 mA, cathode left-DLPFC, anode right-DLPFC; 3: 0.5 mA, anode left-DLPFC, cathode right-DLPFC; 4: 1.5 mA, anode left-DLPFC, cathode left deltoid muscle; 5: sham stimulation). Rs-EEG and TMS-EEG were recorded before and after tDCS.Results: Rs-EEG power spectrum analysis showed no difference comparing baseline with post stimulation in any of the tDCS conditions. TMS-EEG evoked potential amplitude decreased in parietal cortex after 1.5mA left-DLPFC anodal tDCS, and TMS-induced gamma and theta oscillations decreased after all conditions using left-DLPFC anodal tDCS. Left-DLPFC cathodal tDCS did not lead to significant change. None of the post-intervention changes was different when comparing the effects across conditions, including sham.Conclusions: Our study does not provide evidence that a single tDCS session results in significant changes in rs-EEG, using the current stimulation parameters. Significant changes in EEG responses to TMS pulses were observed following the anodal 1.5 mA tDCS interventions, although these changes were not statistically significant in a group comparison. (c) 2018 Elsevier Inc. All rights reserved.