Virus dynamics and drug therapy
Virus dynamics and drug therapy
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DOI：
10.1073/pnas.94.13.6971
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发表时间：
1997-06-24
影响因子：
11.1
通讯作者：
Nowak, MA
中科院分区：
文献类型：
--
作者：
Bonhoeffer, S;May, RM;Nowak, MA
最近开发的有效的抗病毒药物不仅提高了对HIV或B型肝炎病毒感染的有效治疗的希望，而且还导致了对体内病毒动力学的重要定量见解。实验数据的解释依赖于描述病毒和宿主细胞群体之间的非线性相互作用的数学模型。在这里，我们讨论了病毒种群动态，免疫系统在限制病毒丰度的作用，病毒耐药性的动态，以及病毒感染是否可以通过药物治疗从个体患者中消除的问题。
The recent development of potent antiviral drugs not only has raised hopes for effective treatment of infections with HIV or the hepatitis B virus, but also has led to important quantitative insights into viral dynamics in vivo, Interpretation of the experimental data depends upon mathematical models that describe the nonlinear interaction between virus and host cell populations. Here we discuss the emerging understanding of virus population dynamics, the role of the immune system in limiting virus abundance, the dynamics of viral drug resistance, and the question of whether virus infection can be eliminated from individual patients by drug treatment.