Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior.
Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior.
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涡虫：一个多功能且强大的模型系统，用于再生、成体干细胞调节、衰老和行为的分子研究。
DOI：
10.1101/pdb.emo101
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Levin,Michael
中科院分区：
文献类型：
--
作者：
Oviedo,NéstorJ;Nicolas,CindyL;Adams,DanyS;Levin,Michael
近年来，涡虫越来越被认为是一种新兴的模式生物，适合分子遗传学技术，旨在了解后生动物中常见的复杂生物学任务。越来越多的证据表明，这种模式生物具有独特的优势，可以让我们了解组织再生、干细胞调节、组织更新、各种药物的药理作用、癌症和衰老的机制。本文概述了涡虫模型系统，特别关注 Schmidtea mediterranea 物种。此外，还提供了有关该生物体最流行用途的信息，以及现代基因组资源和技术方法。
In recent years, planarians have been increasingly recognized as an emerging model organism amenable to molecular genetic techniques aimed at understanding complex biological tasks commonly observed among metazoans. Growing evidence suggests that this model organism is uniquely poised to inform us about the mechanisms of tissue regeneration, stem cell regulation, tissue turnover, pharmacological action of diverse drugs, cancer, and aging. This article provides an overview of the planarian model system with special attention to the species Schmidtea mediterranea. Additionally, information is provided about the most popular use of this organism, together with modern genomic resources and technical approaches.