The music of lipids: How lipid composition orchestrates cellular behaviour
The music of lipids: How lipid composition orchestrates cellular behaviour
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脂质的音乐：脂质成分如何协调细胞行为
DOI：
10.3109/0284186x.2011.643823
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发表时间：
2012
期刊：
影响因子：
3.1
通讯作者：
E. Gottlieb
中科院分区：
文献类型：
--
作者：
Z. Schug;C. Frezza;L. Galbraith;E. Gottlieb
背景资料。脂类最为人所知的是它们在形成生物膜和作为细胞内信号分子方面的基本作用。蛋白质和脂类之间的相互作用几乎是每个细胞过程的核心，但这些关键的关系往往被忽视。细胞脂谱的改变或转换会极大地影响细胞新陈代谢和信号转导。在与癌症的关系中，脂质代谢的上调通常在肿瘤的早期阶段被观察到，并且是许多类型癌症的公认的标志。方法：研究方法。我们使用PubMed对关于癌症中的脂代谢以及蛋白质-脂相互作用在线粒体功能中的重要性的文献进行了全面的综述。结果。新生脂肪生成的基础速率的增加会导致细胞膜饱和脂肪酸含量的大幅增加。随之而来的磷脂酰链结构的改变对细胞器和膜结合蛋白的功能产生了严重的影响，并导致了包括心脏疾病Barth综合征在内的一系列病理变化。结论。尽管脂肪生成增加是在细胞转化过程中专门选择的，但目前尚不清楚它是对生存有利，还是细胞新陈代谢更具全球性变化的副产品。我们讨论了目前关于靶向生脂开关作为癌症治疗的可能性的数据。此外，我们描述了线粒体磷脂组成在一些线粒体驱动的事件中的重要性，这些事件被观察到在癌症中起到了作用。我们特别强调了心磷脂在维持线粒体结构、调节线粒体动力学和生物能量学方面的作用，以及它在有丝分裂/自噬和细胞凋亡中的作用。
Background. Lipids are best known for their fundamental role in forming biological membranes and as intracellular signalling molecules. Interactions between proteins and lipids are central to nearly every cellular process yet these crucial relationships often go overlooked. Changes or switches in the lipid profile of a cell drastically affects cellular metabolism and signal transduction. In relationship to cancer, upregulation of lipid metabolism is often observed during the early stages of neoplasia and is a recognised hallmark of many types of cancer. Methods. We performed a comprehensive review of the literature using PubMed regarding lipid metabolism in cancer and the importance of protein-lipid interactions in the function of mitochondria. Results. An increase in the basal rate of de novo lipogenesis generates a substantial rise in the saturated fatty acid content of cellular membranes. The ensuing alteration in the acyl chain profile of phospholipids has severe consequences on the function of organelles and membrane-bound proteins, and result in a host of pathologies including the cardiac disorder Barth Syndrome. Conclusions. Although increased lipogenesis is specifically selected for during cellular transformation it remains unclear if it confers an advantage for survival or is a byproduct of more global changes in cellular metabolism. We discuss the current data regarding the potential of targeting the lipogenic switch as a cancer therapy. In addition, we describe the importance of mitochondrial phospholipid composition during a number mitochondria-driven events observed to have roles in cancer. We specifically highlight the function of cardiolipin in maintaining mitochondrial structure, regulating mitochondrial dynamics and bioenergetics as well as its contributions to mitophagy/autophagy and apoptosis.
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影响因子：
15
作者：
Som, Abhigyan;Yang, Lihua;Wong, Gerard C. L.;Tew, Gregory N.
通讯作者：
Tew, Gregory N.
影响因子：
10.3
作者：
Migita, Toshiro;Ruiz, Stacey;Loda, Massimo
通讯作者：
Loda, Massimo
DOI：
10.2217/fon.10.11
发表时间：
2010-04
期刊：
Future oncology (London, England)
影响因子：
--
作者：
Flavin R;Peluso S;Nguyen PL;Loda M
通讯作者：
Loda M
影响因子：
4.3
作者：
Montero, Joan;Mari, Montserrat;Colell, Anna;Morales, Albert;Basanez, Gorka;Garcia-Ruiz, Carmen;Fernandez-Checa, Jose C.
通讯作者：
Fernandez-Checa, Jose C.
DOI：
10.1083/jcb.200810189
发表时间：
2009-02-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Osman C;Haag M;Potting C;Rodenfels J;Dip PV;Wieland FT;Brügger B;Westermann B;Langer T
通讯作者：
Langer T