Conditioned food aversion in Suncus murinus (house musk shrew) - a new model for the study of nausea in a species with an emetic reflex.
Conditioned food aversion in Suncus murinus (house musk shrew) - a new model for the study of nausea in a species with an emetic reflex.
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Suncus murinus（家麝鼩）的条件性食物厌恶——一种研究具有催吐反射的物种恶心的新模型。
DOI：
10.1016/s0031-9384(01)00538-8
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发表时间：
2001
影响因子：
2.9
通讯作者：
Andrews,PL
中科院分区：
文献类型：
--
作者：
Smith,JE;Friedman,MI;Andrews,PL
由于缺乏一种具有呕吐反射的小动物模型，可以研究条件性食物厌恶和呕吐之间的关系，因此对食虫动物臭鼩（Suncus murinus）进行了研究。将一种新型食物（金枪鱼或鸡猫粮）与单次暴露于尼古丁（4 mg/kg皮下）、运动（1 Hz，4 cm，10 min）或氯化锂（100 mg/kg ip）配对（C+）或配对（C-）与生理盐水或假运动暴露。尼古丁和运动都能引起呕吐（干呕/呕吐），但氯化锂不会。所有三个治疗产生了一个条件的食物厌恶后，一个单一的配对与消费的C+食物。当在两种食物中做出选择时，S。氯化锂组、运动暴露组和尼古丁组的C+食物摄入量分别为25%、23%和1%。这项研究表明，条件性食物厌恶可以很容易地诱导在S。murinus和呕吐的诱导可以从食物厌恶解耦。S. murinus提供了一个很有前途的新模型，其中呕吐，恶心和条件性食物厌恶之间的关系可以调查。
The lack of a small animal model with an emetic reflex in which the relationship between conditioned food aversion and emesis could be investigated prompted a study of the insectivore, Suncus murinus (the house musk shrew). A novel food (either tuna or chicken cat food) was paired (C+) with a single exposure to either nicotine (4 mg/kg sc), motion (1 Hz, 4 cm, 10 min) or lithium chloride (100 mg/kg ip) or was paired (C−) with either saline or sham exposure to motion. Nicotine and motion both induced emesis (retching/vomiting) but lithium chloride did not. All three treatments produced a conditioned food aversion after a single pairing with consumption of C+ food. When given a choice between the two foods, S. murinus given lithium chloride, motion exposure and nicotine consumed, respectively, only 25%, 23% and 1% of their total intake from the C+ food. This study shows that a conditioned food aversion can be readily induced in S. murinus and that the induction of emesis can be uncoupled from food aversion. S. murinus provides a promising new model in which the relationship between emesis, nausea and conditioned food aversion can be investigated.