Caenorhabditis elegans:: A versatile platform for drug discovery
Caenorhabditis elegans:: A versatile platform for drug discovery
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DOI：
10.1002/biot.200600176
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发表时间：
2006-12-01
影响因子：
4.7
通讯作者：
Tavernarakis, Nektarios
中科院分区：
文献类型：
--
作者：
Artal-Sanz, Marto;de Jong, Liesbeth;Tavernarakis, Nektarios
药物发现和药物靶标识别是旨在有效对抗人类病理状况的干预策略的两个密切相关的方面。简单的模型生物体为设计和简化有效的药物发现和药物靶标识别方法提供了有吸引力的平台。线虫秀丽隐杆线虫已成为一种特别方便且多功能的工具，可用于实现这些目标。尽管线虫是模式生物库中相对现代的新成员，但其生物学研究已达到特殊水平。再加上轻松的处理以及显着较低的培养和维护成本，可以无缝实施高通量药物筛选方法以及对特定药物靶向的分子途径进行深入的遗传和生化研究。在这篇综述中，我们介绍了秀丽隐杆线虫作为一种模式生物，在识别分子药物靶点方面具有显着优势。此外，我们还讨论了该蠕虫在药物筛选和药物评估方案制定中的价值。线虫的独特特征极大地促进了药物研究，为破译疾病发病机制和制定有根据的有效治疗干预措施带来了希望。
Drug discovery and drugtarget identification are two intimately linked facets of intervention strategies aimed at effectively combating pathological conditions in humans. Simple model organisms provide attractive platforms for devising and streamlining efficient drug discovery and drug target identification methodologies. The nematode worm Coenorhobditis elegans has emerged as a particularly convenient and versatile tool that can be exploited to achieve these goals. Although C. elegans is a relatively modern addition to the arsenal of model organisms, its biology has already been investigated to an exceptional level. This, coupled with effortless handling and a notable low cost of cultivation and maintenance, allows seamless implementation of high-throughput drug screening approaches as well as in-depth genetic and biochemical studies of the molecular pathways targeted by specific drugs. In this review, we introduce C. elegans as a model organism with significant advantages toward the identification of molecular drug targets. In addition, we discuss the value of the worm in the development of drug screening and drug evaluation protocols. The unique features of C elegans, which greatly facilitate drug studies, hold promise for both deciphering disease pathogenesis and formulating educated and effective therapeutic interventions.