ENZYMATIC INCORPORATION OF A NEW BASE PAIR INTO DNA AND RNA EXTENDS THE GENETIC ALPHABET
ENZYMATIC INCORPORATION OF A NEW BASE PAIR INTO DNA AND RNA EXTENDS THE GENETIC ALPHABET
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DOI：
10.1038/343033a0
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发表时间：
1990-01-04
期刊：
影响因子：
64.8
通讯作者：
BENNER, SA
中科院分区：
文献类型：
--
作者：
PICCIRILLI, JA;KRAUCH, T;BENNER, SA
一个新的Watson-Crick碱基对，具有不同于A·T和G·C碱基对的氢键模式，通过DNA和RNA聚合酶掺入双链DNA和RNA中，并将遗传字母表从4个扩展到6个。这种扩展可能导致RNA具有更大的官能团多样性和更大的催化潜力。
A new Watson-Crick base pair, with a hydrogen bonding pattern different from that in the A·T and G·C base pairs, is incorporated into duplex DNA and RNA by DNA and RNA polymerases and expands the genetic alphabet from 4 to 6 letters. This expansion could lead to RNAs with greater diversity in functional groups and greater catalytic potential.