Importance of transcription factors in the regulation of plant secondary metabolism and their relevance to the control of terpenoid accumulation
Importance of transcription factors in the regulation of plant secondary metabolism and their relevance to the control of terpenoid accumulation
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DOI：
10.1007/s11101-006-9000-x
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发表时间：
2006-01-01
影响因子：
7.7
通讯作者：
Leibman, Mark
中科院分区：
文献类型：
--
作者：
Broun, Pierre;Liu, Yan;Leibman, Mark
已知转录因子通过控制途径基因的表达水平，在调节通过次级代谢途径的通量中起关键作用。这种调节机制似乎是重要的萜类化合物的途径，许多应力诱导和存储的萜类化合物的积累往往遵循协调诱导的途径基因。虽然类黄酮途径的调节因子的知识体系已经相当大，控制植物萜类化合物积累的转录因子才刚刚开始被确定。除了它们在代谢控制中的作用之外，转录因子在产生和积累萜类化合物的细胞的分化中也是必不可少的。特别是，它们似乎在腺毛的起始和分化中起重要作用，腺毛是植物中萜类化合物积累的主要场所。我们在这里提出了一些最近的研究结果，这些重要的调节蛋白在次生代谢和萜类化合物的生物合成中所发挥的作用，以及图片，开始出现的分化和代谢过程中的影响，导致萜类化合物在植物中的积累。
Transcription factors are known to play a key role in regulating flux through pathways of secondary metabolism, by controlling the levels of pathway gene expression. This regulatory mechanism seems to be important for the terpenoid pathway, as accumulation of many stress-induced and stored terpenoids often follows coordinated induction of pathway genes. Whereas the body of knowledge on regulators of the flavonoid pathway is already quite large, transcription factors controlling plant terpenoid accumulation are just starting to be identified. In addition to their role in metabolic control, transcription factors are also essential in the differentiation of cells that produce and accumulate terpenoids. In particular, they appear to play an important role in the initiation and differentiation of glandular trichomes, which are a major site of terpenoid accumulation in plants. We are presenting here some of the recent findings on the role played by these important regulatory proteins in secondary metabolism and in terpenoid biosynthesis, as well as the picture that is starting to emerge of their implication in differentiation and metabolic processes leading to the accumulation of terpenoids in plants.