Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.
Recent discoveries on absorption of dietary fat: Presence, synthesis, and metabolism of cytoplasmic lipid droplets within enterocytes.
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DOI：
10.1016/j.bbalip.2016.04.012
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Buhman KK
中科院分区：
文献类型：
--
作者：
D'Aquila T;Hung YH;Carreiro A;Buhman KK
膳食脂肪提供必需营养素，有助于能量平衡，并调节血脂浓度。这些功能对健康很重要，但也可能变得失调，导致肥胖、糖尿病、心血管疾病和癌症等疾病。在肠细胞内，膳食脂肪的消化产物被重新合成为三酰基甘油，其要么分泌在乳糜微粒上，要么储存在细胞质脂滴（CLDs）中。CLDs最初被认为是中性脂质的惰性储存，但现在被认为是除脂质代谢外在多种细胞过程中起作用的动态细胞器。这篇综述将重点介绍与膳食脂肪吸收有关的最新发现，重点是在这一过程中细胞质脂滴的存在、合成和代谢。
Dietary fat provides essential nutrients, contributes to energy balance, and regulates blood lipid concentrations. These functions are important to health, but can also become dysregulated and contribute to diseases such as obesity, diabetes, cardiovascular disease, and cancer. Within enterocytes, the digestive products of dietary fat are re-synthesized into triacylglycerol, which is either secreted on chylomicrons or stored within cytoplasmic lipid droplets (CLDs). CLDs were originally thought to be inert stores of neutral lipids, but are now recognized as dynamic organelles function in multiple cellular processes in addition to lipid metabolism. This review will highlight recent discoveries related to dietary fat absorption with an emphasis on the presence, synthesis, and metabolism of cytoplasmic lipid droplets within this process.
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