IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
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DOI：
10.1016/s1074-7613(00)80477-x
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发表时间：
1998-02-01
期刊：
影响因子：
32.4
通讯作者：
Finkelman, FD
中科院分区：
文献类型：
--
作者：
Urban, JF;Noben-Trauth, N;Finkelman, FD
尽管白细胞介素 - 4（IL - 4）能诱导从免疫缺陷小鼠体内排出胃肠道线虫寄生虫巴西日圆线虫，但这种寄生虫在白细胞介素 - 4缺陷型小鼠体内也能正常排出。通过观察发现白细胞介素 - 4受体α链（IL - 4Rα）缺陷型小鼠和信号转导及转录激活因子6（Stat6）缺陷型小鼠无法排出巴西日圆线虫，以及白细胞介素 - 13（IL - 13，它是另一种通过IL - 4Rα激活Stat6的因子）的一种特异性拮抗剂可阻止蠕虫排出，这就解释了上述明显的矛盾现象。因此，巴西日圆线虫的排出需要通过IL - 4Rα和Stat6进行信号传导，并且作为导致蠕虫排出的Stat6信号传导的诱导因子，白细胞介素 - 13可能比白细胞介素 - 4更为重要。在这些实验过程中所做的其他观察表明，Stat6信号传导对于白细胞介素 - 4增强IgG1的产生不是必需的，实际上还会抑制白细胞介素 - 4诱导的黏膜肥大细胞增多。
Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient mice. This apparent paradox is explained by observations that IL-4 receptor alpha chain (IL-4R alpha)-deficient mice and Stat6-deficient mice fail to expel N. brasiliensis, and a specific antagonist for IL-13, another activator of Stat6 through IL-4R alpha, prevents worm expulsion. Thus, N. brasiliensis expulsion requires signaling via IL-4R alpha and State, and IL-13 may be more important than IL-4 as an inducer of the State signaling that leads to worm expulsion. Additional observations made in the course of these experiments demonstrate that State signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL-4-induction of mucosal mastocytosis.