Vernier threshold in patients with schizophrenia and in their unaffected siblings
Vernier threshold in patients with schizophrenia and in their unaffected siblings
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DOI：
10.1037/0894-4105.18.3.537
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发表时间：
2004-07-01
期刊：
影响因子：
2.4
通讯作者：
Janka, Z
中科院分区：
文献类型：
--
作者：
Kéri, S;Kelemen, O;Janka, Z
本研究的目的是调查大细胞（M）和小细胞（P）的视觉功能，在非药物治疗的精神分裂症患者和他们的健康同胞。视网膜感受野皮质整合可能的异常也被提出。22名未经药物治疗的精神分裂症患者，他们未受影响的兄弟姐妹和20名年龄和智商匹配的健康对照受试者接受了4项游标视力任务（蓝黄，倍频，消色差低和高对比度条件），他们被要求检测点和光栅的空间对齐。结果显示，精神分裂症患者和他们的健康同胞在倍频和消色差低对比度条件下表现出选择性功能障碍，这些条件用于研究M通路。在等亮度蓝黄和高对比度消色差条件下，实验组之间没有显著差异。这些结果提示，M通路缺陷是精神分裂症的一种内表型。
The aim of this study was to investigate magnocellular (M) and parvocellular (P) visual functions in nonmedicated patients with schizophrenia and in their unaffected siblings. Possible abnormalities in cortical integration of retinal receptive fields also were addressed. Twenty-two nonmedicated patients with schizophrenia, their unaffected siblings, and 20 age- and IQ-matched healthy control subjects received 4 Vernier acuity tasks (blue-on-yellow, frequency-doubling, achromatic low and high contrast conditions) in which they were asked to detect the spatial alignment of dots and gratings. Results revealed that the patients with schizophrenia and their unaffected siblings showed selective dysfunctions in the frequency-doubling and achromatic low contrast conditions, which were devoted to investigate M pathways. In the isoluminant blue-on-yellow and high contrast achromatic conditions, there were no significant differences between the experimental groups. These results suggest that the deficit of M pathway is an endophenotype of schizophrenia.