Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent
Changes in caudate volume after exposure to atypical neuroleptics in patients with schizophrenia may be sex-dependent
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DOI：
10.1016/j.schres.2003.08.008
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发表时间：
2004-02-01
影响因子：
4.5
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
--
作者：
Heitmiller, DR;Nopoulos, PC;Andreasen, NC
背景资料：精神分裂症患者尾状核体积随时间的变化已被证明与抗精神病药物暴露直接相关。很少有研究评估了精神分裂症患者的尾状核体积，这些患者在摄入抗精神病药物时未接受过治疗，并且只接受非典型抗精神病药物治疗。方法：14例患者按性别与14名健康对照者相匹配，并使用MRI随时间进行评估。这些患者在入院时未接受过抗精神病药物治疗，在随访时仅接受过非典型抗精神病药物治疗。计算尾状核体积的差异评分。使用剂量-年公式对精神抑制剂暴露进行量化。结果：在尾状核体积随时间的变化量方面，患者和对照组之间没有差异。然而，女性患者的药物暴露量与体积变化呈负相关（r =-0.74），而男性患者则呈正相关（r = 0.63）。因此，非典型抗精神病药物暴露与尾状核结构随时间变化之间的关系存在显著的性别效应（相关性差异检验：z = 2.39，p = 0.016）。结论：暴露于非典型抗精神病药物后尾状核体积随时间的变化可能具有性别依赖性。非典型的精神抑制剂expsoure与体积增加随着时间的推移，在男性，而在女性的暴露量随着时间的推移与体积递减。(C)2003 Elsevier B. V.保留所有权利。
Background: Changes in the volume of the caudate nucleus over time in patients with schizophrenia has been shown to be directly related to neuroleptic exposure. Few studies have evaluated caudate volume in subjects with schizophrenia who were neuroleptic naive at intake and treated exclusively with atypical neuroleptics. Methods: Fourteen patients were matched by gender to 14 healthy controls and were evaluated over time using MRI. The patients were neuroleptic naive at intake and at follow-up had been treated exclusively with atypical neuroleptics. Difference scores were calculated for caudate volumes. Neuroleptic exposure was quantified using a dose-years formula. Results: There was no difference between patients and controls in the amount of change over time in the volume of the caudate. However, the female patients had a negative correlation (r = - 0.74) between drug exposure and volume change while the male patients had a positive correlation (r = 0.63). Therefore, there was a significant gender effect on the relationship between atypical neuroleptic exposure and changes in the structure of the caudate over time (test for difference in correlations: z = 2.39, p = 0.016). Conclusions: The change in caudate nucleus volume over time with exposure to atypical neuroleptics may be sex-dependent. Atypical neuroleptic expsoure was associated with volume increase over time in the males, while exposure in females was associated with volume decrement over time. (C) 2003 Elsevier B.V. All rights reserved.