Brain choline acetyltransferase reduction in SIV infection. An index of early dementia?
Brain choline acetyltransferase reduction in SIV infection. An index of early dementia?
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DOI：
10.1097/00001756-200008030-00011
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发表时间：
2000-08-03
期刊：
影响因子：
1.7
通讯作者：
Riederer, P
中科院分区：
文献类型：
--
作者：
Koutsilieri, E;Czub, S;Riederer, P
晚期艾滋病毒感染与神经系统并发症有关，包括运动和认知功能受损。我们使用猴免疫缺陷（SIV）感染的恒河猴，HIV感染的动物模型，调查胆碱乙酰转移酶（ChAT）活性的变化，认知功能的生化标志物，在死后的大脑在早期，无症状的SIV感染和艾滋病。在无症状感染期间，壳核和海马中的ChAT活性已经显著降低。在患有艾滋病的动物中，ChAT活性进一步降低。ChAT的降低与脑病毒载量及中枢神经系统病变无关。我们的结果表明，在SIV感染的头几个月内，ChAT活性已经出现缺陷，并意味着认知功能障碍可能在免疫缺陷病毒感染的早期发生。NeuroReeort 11：2391-2393（C）2000 Lippincott威廉姆斯和威尔金斯。
HIV infection at late stages is associated with neurological complications including impaired motor and cognitive functions. We used simian immunodeficiency (SIV)-infected rhesus monkeys, an animal model of HIV infection, to investigate changes in choline acetyltransferase (ChAT) activity, a biochemical marker of cognitive function, in post-mortem brains during early, asymptomatic SIV infection and AIDS. ChAT activity was dramatically reduced in putamen and hippocampus already during asymptomatic infection. In animals with AIDS, ChAT activity was further decreased. The reduction of ChAT was not related to brain viral load or CNS pathological lesions. Our results demonstrate deficits in ChAT activity already during the first months of SIV infection and imply that cognitive dysfunction may occur early in immunodeficiency viral infections. NeuroReeort 11:2391-2393 (C) 2000 Lippincott Williams & Wilkins.