Inactivation of clinical isolates of Herpesvirus hominis, types 1 and 2, by chemical contraceptives.
Inactivation of clinical isolates of Herpesvirus hominis, types 1 and 2, by chemical contraceptives.
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通过化学避孕药灭活 1 型和 2 型人疱疹病毒临床分离株。
DOI：
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发表时间：
1978
影响因子：
3.1
通讯作者：
L. Guevarra
中科院分区：
文献类型：
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作者：
B. Postic;B. Singh;N. Squeglia;L. Guevarra
研究了两种化学避孕药对人疱疹病毒2型和1型各4种毒株的杀病毒作用。其中7个菌株代表最近的临床分离株; 1个菌株是2型原型。在室温或体温下接触10分钟后，两种杀虫剂都降低了所有八种病毒的感染性。新的杀精子剂-杀菌剂化合物A在0.05%的低浓度下产生抗病毒作用，而市售的Preceptin在5%下有效，但在0.5%下无效。病毒感染性的实质性丧失是由于杀精子剂直接灭活病毒，而不是继发于细胞毒性或用于试验的细胞培养物中干扰素的诱导。这些体外研究结果为阻断H的性传播提供了依据。人类
Two chemical contraceptives were examined for virucidal effects against four strains each of Herpesvirus hominis, type 2 and 1. Seven of the strains represented recent clinical isolates; one strain was a type 2 prototype. Either psermicide reduced the infectivities ofall eight viruses after contact for 10 minutes at room or body temperature. The new spermicide-germicide, compound A, produced an antiviral effect at the low concentration of 0.05%, whereas the commercially available Preceptin was effective at 5%, but not at 0.5%. The substantial loss of viral infectivity was due to direct inactivation of virus by the spermicides and was not secondary to cytotoxicity or induction of interferon in the cell cultures used for the assay. These in vitro findings hold primse for the interruption of the sexual transmission of H. hominis.