Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis.
Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis.
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DOI：
10.1186/s13046-022-02520-0
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发表时间：
2022-10-28
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当肿瘤细胞从原发性肿瘤中分离出来，进入循环（循环肿瘤细胞，CTC）并在骨中定植（弥散性肿瘤细胞，DTC）时，就会发生骨转移。骨髓似乎是一个特别的休眠诱导环境的DTC，但休眠启动，再激活和骨髓内的相互作用的机制必须阐明。有趣的是，一些证据表明，休眠是一种可逆的状态，取决于各种骨髓驻留细胞的存在，特别是破骨细胞和成骨细胞的存在，可以“打开”或“关闭”。已经清楚的是，这两种细胞有助于直接（相互作用）和间接（分泌因子）调节骨中的休眠肿瘤细胞。所涉及的机制包括TGFβ信号传导、Wnt信号传导轴、Notch2通路等。目前还没有详细的综述专门关注肿瘤细胞休眠和骨重建之间的动态相互作用。此外，我们强调了炎症细胞因子在这种“细胞间”交流中的作用。我们还讨论了在控制休眠肿瘤细胞中重塑骨髓小生境的潜在临床意义。了解破骨细胞和成骨细胞在调节骨髓肿瘤休眠中的独特作用，将为预防和治疗肿瘤骨转移提供新的见解。
Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow seems to be a particularly dormancy-inducing environment for DTCs, yet the mechanisms of dormancy initiation, reactivation, and interaction within the bone marrow have to be elucidated. Intriguingly, some evidence has suggested that dormancy is a reversible state that is switched ‘on’ or ‘off’ depending on the presence of various bone marrow resident cells, particularly osteoclasts and osteoblasts. It has become clear that these two cells contribute to regulating dormant tumour cells in bone both directly (interaction) and indirectly (secreted factors). The involved mechanisms include TGFβ signalling, the Wnt signalling axis, the Notch2 pathway, etc. There is no detailed review that specifically focuses on ascertaining the dynamic interactions between tumour cell dormancy and bone remodelling. In addition, we highlighted the roles of inflammatory cytokines during this ‘cell-to-cell’ communication. We also discussed the potential clinical relevance of remodelling the bone marrow niche in controlling dormant tumour cells. Understanding the unique role of osteoclasts and osteoblasts in regulating tumour dormancy in bone marrow will provide new insight into preventing and treating tumour bone metastasis.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
3.9
作者：
Han HH;Kim BG;Lee JH;Kang S;Kim JE;Cho NH
通讯作者：
Cho NH
影响因子：
20.3
作者：
Cackowski, Frank C.;Anderson, Judith L.;Roodman, G. David
通讯作者：
Roodman, G. David
影响因子：
45.3
作者：
Gnant, Michael F. X.;Mlineritsch, Brigitte;Jakesz, Raimund
通讯作者：
Jakesz, Raimund
影响因子：
20.3
作者：
Boyerinas, Benjamin;Zafrir, Maya;Sipkins, Dorothy A.
通讯作者：
Sipkins, Dorothy A.