Maintenance of Arterial Pressure by Vasopressin and Angiotensin II after Adfenalectomy
Maintenance of Arterial Pressure by Vasopressin and Angiotensin II after Adfenalectomy
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肾上腺切除术后加压素和血管紧张素 II 维持动脉压
DOI：
10.1161/01.hyp.5.6_pt_3.v53
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发表时间：
1983
期刊：
影响因子：
8.3
通讯作者：
L. Krakoff
中科院分区：
文献类型：
--
作者：
Fernando Eluovich;M. Kirchberger;C. Barry;L. Krakoff
在未麻醉的肾上腺切除大鼠中评估加压素和肾素-血管紧张素系统在维持全身动脉压中的作用。肾上腺切除术和植入动脉和静脉导管的假手术大鼠在肾上腺切除术后72小时内给予1%氯化钠和2.5%葡萄糖作为饮用液。获取血清和尿液样本用于测量电解质和溶质浓度。在肾上腺切除大鼠中观察到的血清电解质、血清渗透压以及电解质、溶质和水的肾脏排泄模式与该模型中先前的观察结果完全一致。未麻醉、不受约束的肾上腺切除大鼠的平均动脉压显着低于对照组。在肾上腺切除的大鼠中，dPMeTyrAVP 使平均动脉压降低 9 ± 1 mm Hg，p < 0.001；卡托普利导致血压进一步降低 17 ± 2 mm Hg，p < 0.01。两种拮抗剂均未改变对照组的动脉压。我们的研究结果表明，加压素和肾素-血管紧张素系统在肾上腺皮质功能不全中发挥代偿性升压作用，防止慢性低血压模型中动脉压大幅下降。
Participation of vasopressin arid the renin-anglotensin system in the maintenance, of systemic arterial pressure was evaluated in unanesthetized adrenalectomized rats. Adrenalectomized and sham-operated rats with implanted arterial and venous catheters were given 1% sodium chloride and 2.5% glucose as drinking fluid for 72 hours following adrenalectomy. Serum and urine samples were obtained for measurement of electrolyte and solute concentration. The pattern of serum electrolytes, serum osmolality, and renal excretion of electrolytes, solute, and water observed in the adrenalectomized rats was entirely consistent with previous observations in this model. Mean arterial pressure of unanesthetized unrestrained adrenalectomized rats was significantly lower than controls. In adrenalectomized rats, dPMeTyrAVP reduced mean arterial pressure 9 ± 1 mm Hg, p < 0.001; captopril then caused an additional reduction of 17 ± 2 mm Hg, p < 0.01. Neither antagonist altered arterial pressure in the control group. Our results indicate that vasopressin and the renin-angiotensin system play a compensatory pressor role in adrenal insufficiency, preventing a larger decrease of arterial pressure in this model of chronic hypotension.
加压素在肾上腺功能不全期间血压调节中的作用。
影响因子：
4.8
作者：
Schwartz,J;Keil,LC;Maselli,J;Reid,IA
通讯作者：
Reid,IA