Functional Status Scale: new pediatric outcome measure.
Functional Status Scale: new pediatric outcome measure.
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DOI：
10.1542/peds.2008-1987
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发表时间：
2009-07
期刊：
影响因子：
8
通讯作者：
Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network
中科院分区：
文献类型：
--
作者：
Pollack MM;Holubkov R;Glass P;Dean JM;Meert KL;Zimmerman J;Anand KJ;Carcillo J;Newth CJ;Harrison R;Willson DF;Nicholson C;Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network
为大型结局研究创建功能状态结局指标，该指标定义明确、定量、足够快速、可靠、对主观评估的依赖性最小，适用于各种年龄和住院环境的住院儿科患者。功能状态量表（FSS）是由多学科共识过程开发的。功能领域包括精神状态、感觉、交流、运动、进食和呼吸，从正常到非常严重的功能障碍。适应性行为评估系统（ABAS）II建立了结构效度和领域内的校准。7家机构提供了儿科重症监护病房（PICU）出院24小时内的患者、入院24小时内的高危非PICU患者、技术依赖儿童。初级保健护士完成了ABAS II的基础上，患者的功能，当FSS完成。使用10%研究日的患者评价评价者间可靠性。将数据随机分为估计集和验证集。统计分析包括Pearson相关、结构效度、线性回归分析、判别效度的受试者工作特征（ROC）曲线分析和评分者间信度的组内相关。共有836名儿童的平均FSS为10.3（标准差4.4）进行了研究。18%的患者最低可能的FSS = 6，44%的患者FSS ≥ 10，14%的患者FSS ≥ 15，6%的患者FSS评分≥ 20。每个FSS域与平均ABAS II相关（p<.0001）。每个域中的单元格都被折叠并重新加权，这使得估计样本与ABAS II的相关性从-0.58提高到-0.62，验证样本从-0.60提高到-0.63（p<0.001）。对于中度和重度功能障碍（ABAS II类别）的区分度非常好，并且通过FSS加权得到改善（ROC曲线下面积> 0.8）。原始和加权总FSS的组内相关系数分别为0.95和0.94。FSS达到了我们的目标，非常适合大型结局研究。
To create a functional status outcome measure for large outcome studies that is well defined, quantitative, sufficiently rapid, reliable, minimally dependent on subjective assessments, and applicable to hospitalized pediatric patients across a wide spectrum of ages and inpatient environments. The Functional Status Scale (FSS) was developed by a multidisciplinary consensus process. Domains of functioning included mental status, sensory, communication, motor, feeding, and respiratory categorized from normal to very severe dysfunction. The Adaptive Behavior Assessment System (ABAS) II established construct validity and calibration within domains. Seven institutions provided pediatric intensive care unit (PICU) patients within 24 hours of PICU discharge, high-risk non-PICU patients within 24 hours of admission, and technology-dependent children. Primary care nurses completed the ABAS II based on patient’s functioning when the FSS was completed. Patients from 10% of the study days were used to evaluate inter-rater reliability. Data were randomly split into estimation and validation sets. Statistical analyses included Pearson correlations, construct validity, linear regression analysis, receiver operating characteristic (ROC) curve analysis for discriminant validity, and the intraclass correlation for inter-rater reliability. A total of 836 children with a mean FSS of 10.3 (standard deviation 4.4) were studied. Eighteen percent had the minimum possible FSS = 6, 44% had FSS ≥ 10, 14% had a FSS ≥ 15, and 6% had FSS scores ≥ 20. Each FSS domain was associated with mean ABAS II (p<.0001). Cells in each domain were collapsed and reweighted, which improved correlations with ABAS II from −0.58 to −0.62 in the estimation sample, and −0.60 to −0.63 in the validation sample (p<0.001 for improvements). Discrimination was very good for moderate and severe dysfunction (ABAS II categories) and improved with FSS weighting (area under the ROC curve > 0.8). Intraclass correlations of original and weighted total FSS were 0.95 and 0.94 respectively. The FSS met our objectives and is well suited for large outcome studies.
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影响因子：
8.8
作者：
Fiser, DH;Tilford, JM;Roberson, PK
通讯作者：
Roberson, PK
影响因子：
120.7
作者：
POLLACK, MM;CUERDON, TT;LEVETOWN, M
通讯作者：
LEVETOWN, M
影响因子：
1.9
作者：
DELONG, ER;DELONG, DM;CLARKEPEARSON, DI
通讯作者：
CLARKEPEARSON, DI
DOI：
10.1046/j.1532-5415.2003.51152.x
发表时间：
2003-04-01
影响因子：
6.3
作者：
Covinsky, KE;Palmer, RM;Landefeld, CS
通讯作者：
Landefeld, CS
影响因子：
--
作者：
Hotelling, H
通讯作者：
Hotelling, H