Toxoplasma gondii infection and the risk of adult glioma in two prospective studies
Toxoplasma gondii infection and the risk of adult glioma in two prospective studies
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DOI：
10.1002/ijc.33443
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发表时间：
2021-01-11
影响因子：
6.4
通讯作者：
Egan, Kathleen M.
中科院分区：
文献类型：
--
作者：
Hodge, James M.;Coghill, Anna E.;Egan, Kathleen M.
弓形虫（T gondii）是一种常见的寄生虫，对神经组织表现出亲和力，并可能导致脑内囊肿的形成。以前的流行病学研究表明胶质瘤与弓形虫感染患病率增加之间存在联系，但缺乏前瞻性研究。因此，我们采用巢式病例对照研究设计，在两个前瞻性队列中研究了诊断前弓形虫抗体与胶质瘤风险之间的关系。病例和匹配对照选自美国癌症协会癌症预防研究-II营养队列（CPSII-NC）（n = 37例和74例对照）和挪威癌症登记处的Janus血清库（Janus）（n = 323例和323例对照）。分析诊断前收集的血液样本中是否存在针对两种弓形虫表面抗原（p22和sag-1）的抗体，如果检测到针对任何一种抗原的抗体，则认为个体血清反应呈阳性。使用条件logistic回归计算每个队列的比值比（OR）和95%置信区间（95%CI）。在这两个队列中，在弓形虫感染者中观察到胶质瘤风险的暗示性增加（CPSII-NC的OR：2.70; 95% CI：0.96-7.62; Janus的OR：1.32，95% CI：0.85-2.07），尤其是在具有sag-1抗原特异性高抗体滴度的参与者中（CPSII-NC OR：3.35，95% CI：0.99-11.38; Janus OR：1.79，95% CI：1.02-3.14）。我们的研究结果提供了第一个前瞻性的证据表明弓形虫感染和神经胶质瘤的风险之间的关联。需要更多病例的进一步研究来证实弓形虫在胶质瘤中的潜在病因作用。
Toxoplasma gondii (T gondii) is a common parasite that shows affinity to neural tissue and may lead to the formation of cysts in the brain. Previous epidemiologic studies have suggested an association between glioma and increased prevalence of T gondii infection, but prospective studies are lacking. Therefore, we examined the association between prediagnostic T gondii antibodies and risk of glioma in two prospective cohorts using a nested case-control study design. Cases and matched controls were selected from the American Cancer Society's Cancer Prevention Study-II Nutrition Cohort (CPSII-NC) (n = 37 cases and 74 controls) and the Norwegian Cancer Registry's Janus Serum Bank (Janus) (n = 323 cases and 323 controls). Blood samples collected prior to diagnosis were analyzed for antibodies to two T gondii surface antigens (p22 and sag-1), with individuals considered seropositive if antibodies to either antigen were detected. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95% CI) for each cohort. In both cohorts, a suggestive increase in glioma risk was observed among those infected with T gondii (OR: 2.70; 95% CI: 0.96-7.62 for CPSII-NC; OR: 1.32, 95% CI: 0.85-2.07 for Janus), particularly among participants with high antibody titers specific to the sag-1 antigen (CPSII-NC OR: 3.35, 95% CI: 0.99-11.38; Janus OR: 1.79, 95% CI: 1.02-3.14). Our findings provide the first prospective evidence of an association between T gondii infection and risk of glioma. Further studies with larger case numbers are needed to confirm a potential etiologic role for T gondii in glioma.