The macrophage scavenger receptor CD163
The macrophage scavenger receptor CD163
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DOI：
10.1016/j.imbio.2005.05.010
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发表时间：
2005-01-01
期刊：
影响因子：
2.8
通讯作者：
van den Berg, TK
中科院分区：
文献类型：
--
作者：
Fabriek, BO;Dijkstra, CD;van den Berg, TK
成熟组织巨噬细胞形成识别和消除潜在病原体的第一道防线;这些特化细胞能够吞噬、降解自身和外来物质、建立细胞-细胞相互作用以及产生炎症介质。成熟组织巨噬细胞表达多种受体，包括清道夫受体富半胱氨酸（SRCR）超家族成员。CD 163是SRCR家族B类成员，在成熟组织巨噬细胞的大多数亚群上表达。CD 163的最佳表征功能（其基本上是稳态功能）与血红蛋白：触珠蛋白复合物的结合有关。此外，已经表明CD 163阳性巨噬细胞或可溶形式的CD 163在炎症消退中起作用，因为它们在发炎组织中大量存在。(C)2005年Elsevier GmbH。All rights reserved.
Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin: Haptoglobin complexes. Furthermore, it has been suggested that CD 163 positive macrophages or the soluble form of CD 163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue. (C) 2005 Elsevier GmbH. All rights reserved.