Galactolipids as potential health promoting compounds in vegetable foods.
Galactolipids as potential health promoting compounds in vegetable foods.
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半乳糖脂作为植物食品中潜在的健康促进化合物。
DOI：
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发表时间：
2009
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通讯作者：
L. Christensen
中科院分区：
文献类型：
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作者：
L. Christensen
半乳糖脂是一类广泛存在于植物界（包括食用植物）中的化合物，是细胞膜的重要组成部分。植物中的半乳糖脂主要由单半乳糖基二酰基甘油和二半乳糖基二酰基甘油组成，含有一个或两个与甘油部分连接的饱和和/或不饱和脂肪酸。几种半乳糖脂已被证明具有体外和/或体内抗肿瘤促进活性和抗炎活性。最近，已证明半乳糖脂 1,2-di-O-α-linolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol (1) 可能对狗蔷薇 (Rosa canina) 的抗炎活性很重要，狗蔷薇是一种药用植物，已证明对关节炎等抗炎疾病具有功效。这种半乳糖脂也以相对较高的浓度存在于某些豆类（例如菜豆、豌豆）、叶类蔬菜（例如羽衣甘蓝、韭葱、欧芹、紫苏和菠菜）、茎类蔬菜（例如芦笋、西兰花、球芽甘蓝）和果类蔬菜（例如辣椒、甜椒、南瓜）中。此外，化合物 1 已通过生物测定引导的分馏从菠菜和几种药用植物中分离出来，作为一种半乳糖脂，可能具有预防癌症的作用。在这篇综述中，讨论了半乳糖脂的生物活性及其作为重要营养保健品在人类饮食中的潜在作用。此外，还介绍并讨论了有关特定半乳糖脂生物活性的最新专利以及利用这些知识的发明。
Galactolipids are a class of compounds widely found in the plant kingdom, including edible plants, and are an important part of the cell membranes. Galactolipids in plants consists mainly of monogalactosyldiacylglycerols and digalactosyldiacylglycerols containing one or two saturated and/or unsaturated fatty acids linked to the glycerol moiety. Several galactolipids have been shown to possess in vitro and/or in vivo anti-tumor promoting activity and anti-inflammatory activity. Recently, it has been demonstrated that the galactolipid, 1,2-di-O-alpha-linolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol (1), may be important for the anti-inflammatory activity of dog rose (Rosa canina), a medicinal plant with documented effect on anti-inflammatory diseases such as arthritis. This galactolipid also occurs in relative high concentrations in certain legumes (e.g., common bean, pea), leaf vegetables (e.g., kale, leek, parsley, perilla and spinach), stem vegetables (e.g., asparagus, broccoli, brussels sprouts), and fruit vegetables (e.g., chilli, bell pepper, pumpkin). Furthermore, compound 1 has been isolated from spinach and several medicinal plants by bioassay-guided fractionation as a galactolipid with possible cancer preventive effects. In this review, the bioactivity of galactolipids is discussed and their potential role in human diet as important nutraceuticals. Moreover, recent patents on the bioactivity of specific galactolipids and inventions making use of this knowledge are presented and discussed.