Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease
Chiral Plasmonic Triangular Nanorings with SERS Activity for Ultrasensitive Detection of Amyloid Proteins in Alzheimer's Disease
复制标题
具有 SERS 活性的手性等离子体三角纳米环用于阿尔茨海默病中淀粉样蛋白的超灵敏检测
DOI：
10.1002/adma.202102337
复制
发表时间：
2021-07-26
影响因子：
29.4
通讯作者：
Xu, Liguang
中科院分区：
文献类型：
--
作者：
Wang, Gaoyang;Hao, Changlong;Xu, Liguang
Chiral plasmonic nanomaterials have attracted unprecedented attention due to their broad applications in biomedicine, negative refractive index, and chiral sensing. Here, using a wet-chemistry process, chiral triangular Au nanorings are fabricated with a platinum (Pt) framework (L/D-Pt@Au triangular nanorings, named L/D-Pt@Au TNRs). The L/D-Pt@Au TNRs exhibit strong optical activity with a g-factor of 0.023 and can be used effectively for the discrimination of enantiomers due to selective resonance coupling between the induced electric and magnetic dipoles associated with enantiomers and the chiral plasmonic TNRs, also known as the surface-enhanced Raman scattering-chiral anisotropy (SERS-ChA) effect. The chiral D-Pt@Au TNRs represent a label-free SERS platform that can be applied to detect A beta monomers and fibrils, the hallmarks of Alzheimer's disease (AD), achieving a limit of detection (LOD) down to 0.045 x 10(-12) m and 4 x 10(-15) m for 42-residue-long amyloid-beta (A beta(42)) monomer and fibrils, respectively. Furthermore, chiral D-Pt@Au TNRs can also be successfully carried out to detect A beta(42) proteins in AD patients with ultrahigh levels of sensitivity, thus allowing picogram quantities of A beta(42) proteins to be identified. This research opens up an avenue for the use of chiral plasmonic nanomaterials as ultrasensitive SERS substrates to early diagnosis of protein-misfolding diseases.
