Role of ABL family kinases in cancer: from leukaemia to solid tumours.
Role of ABL family kinases in cancer: from leukaemia to solid tumours.
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ABL家族激酶在癌症中的作用：从白血病到实体瘤。
DOI：
10.1038/nrc3563
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发表时间：
2013-08
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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Abelson（ABL）家族的非受体酪氨酸激酶ABL1和ABL2将多种细胞外信号转导至控制增殖、存活、迁移和侵袭的蛋白质网络。ABL1最初被鉴定为逆转录病毒或染色体易位引发的白血病发展所需的癌基因。小分子ABL激酶抑制剂有效治疗慢性粒细胞白血病的证明打开了靶向癌症治疗时代的大门。最近的报道揭示了ABL激酶在实体瘤中的作用。在某些实体瘤中增强的ABL表达和活化，以及由活化的ABL激酶诱导的改变的细胞极性、侵袭或生长，表明靶向这些激酶的药物可能在治疗选定的实体瘤中具有效用。
The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse extracellular signals to protein networks that control proliferation, survival, migration, and invasion. ABL1 was first identified as an oncogene required for the development of leukemias initiated by retroviruses or chromosome translocations. The demonstration that small molecule ABL kinase inhibitors effectively treat chronic myeloid leukemia opened the door to the era of targeted cancer therapies. Recent reports have uncovered roles for ABL kinases in solid tumors. Enhanced ABL expression and activation in some solid tumors, together with altered cell polarity, invasion or growth induced by activated ABL kinases, suggest that drugs targeting these kinases may have utility in treating selected solid tumors.
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影响因子：
50.3
作者：
Carretero J;Shimamura T;Rikova K;Jackson AL;Wilkerson MD;Borgman CL;Buttarazzi MS;Sanofsky BA;McNamara KL;Brandstetter KA;Walton ZE;Gu TL;Silva JC;Crosby K;Shapiro GI;Maira SM;Ji H;Castrillon DH;Kim CF;García-Echeverría C;Bardeesy N;Sharpless NE;Hayes ND;Kim WY;Engelman JA;Wong KK
通讯作者：
Wong KK
影响因子：
7.3
作者：
Colicelli J
通讯作者：
Colicelli J
影响因子：
4.8
作者：
Allington, Tressa M.;Galliher-Beckley, Amy J.;Schiemann, William P.
通讯作者：
Schiemann, William P.
影响因子：
4.8
作者：
Cao, Xiaoqing;Tanis, Keith Q.;Colicelli, John
通讯作者：
Colicelli, John
影响因子：
8
作者：
Cao, C;Li, YP;Kufe, D
通讯作者：
Kufe, D