Neuroblastoma incidence and survival in European children (1978-1997): Report from the Automated Childhood Cancer Information System Project
Neuroblastoma incidence and survival in European children (1978-1997): Report from the Automated Childhood Cancer Information System Project
复制标题
DOI：
10.1016/j.ejca.2006.05.008
复制
发表时间：
2006-09-01
影响因子：
8.4
通讯作者：
Steliarova-Foucher, Eva
中科院分区：
文献类型：
--
作者：
Spix, Claudia;Pastore, Guido;Steliarova-Foucher, Eva
自动儿童癌症信息系统(ACCIS)收集并提供欧洲儿童癌症的数据。这份报告描述了来自19个国家59个登记处的6202名神经母细胞瘤儿童的发病率和存活率的趋势(1978-1997年)和地理差异(1988-1997年)，分为五个地区(不列颠群岛、西部、东部、北部和南部)。19881997年欧洲神经母细胞瘤的年龄标化发病率为每百万儿童10.9例，其中婴儿发病率最高(52.6%)。在欧洲，神经母细胞瘤的ASR从1978-1982年的8.4上升到1993-1997年的11.6，主要是由于婴儿的增加(从35.4增加到57.8)。总体5年生存率为59%，从47%(东部)到67%(西部)不等。发病率从1978-1982年的37%显著提高到1993-1997年的66%，尤其是婴儿。在2岁以下儿童中，一定程度的过度诊断可能解释了发病率的增加和部分存活率的增加。年龄较大的儿童(2-14岁)的存活率也从21%提高到45%，这可能在很大程度上受到治疗的影响。(C)2006爱思唯尔有限公司。保留所有权利。
The Automated Childhood Cancer Information System (ACCIS) collects and presents data on childhood cancer in Europe. This report describes trends (1978-1997) and geographical differences (1988-1997) in incidence and survival for 6202 children with neuroblastoma from 59 registries in 19 countries, grouped into five regions (British Isles, West, East, North, and South). The age-standardised incidence rate (ASR) of neuroblastoma in Europe in 19881997 was 10.9 cases per million children, being highest in infants (52.6). The ASR of neuroblastoma increased in Europe from 8.4 in 1978-1982 to 11.6 in 1993-1997, mostly due to an increase in infants (from 35.4 to 57.8). Overall 5-year survival vias 59%, ranging from 47% (East) to 67% (West). It improved markedly from 37% in 1978-1982 to 66% in 1993-1997, especially in infants. A certain amount of overdiagnosis in children under 2 years of age may explain the increased incidence rates and partially the increase in survival. Survival of older children (aged 2-14 years), which is likely to be largely affected by therapy, has also improved from 21% to 45%. (c) 2006 Elsevier Ltd. All rights reserved.