Effect of intrauterine growth restriction an blood pressure, glucose tolerance and sympathetic nervous system activity in the rat at 3-4 months of age
Effect of intrauterine growth restriction an blood pressure, glucose tolerance and sympathetic nervous system activity in the rat at 3-4 months of age
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DOI：
10.1097/00004872-199917090-00002
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发表时间：
1999-09-01
影响因子：
4.9
通讯作者：
Lambert, GW
中科院分区：
文献类型：
--
作者：
Jansson, T;Lambert, GW
目的流行病学研究表明，妊娠期营养不良引起的胎儿宫内生长受限（IUGR）是成年期高血压和糖尿病的主要危险因素。然而，胎盘功能不全，而不是母亲营养不良，是西方世界IUGR的主要原因。因此，我们在建立胎盘功能不全动物模型的基础上，研究了出生体重与成年血压和糖耐量的关系。（n = 41，出生体重范围3.2- 6.6g）使用遥测技术记录72小时内的血压，并测量下丘脑组织的去甲肾上腺素水平。在另一个亚组（n = 30，出生体重范围3.0-6.8克）的交感神经系统（SNS）的活动进行了评估，通过去甲肾上腺素同位素稀释技术和葡萄糖耐量测定的静脉葡萄糖load.Results成人育雏压力是独立的出生体重IUGR大鼠的血流动力学反应，以中等的声音应激是不变的。在雄性大鼠中，SNS活动，下丘脑去甲肾上腺素浓度和葡萄糖耐量均与出生体重无关。相反，IUGR在雌性大鼠与SNS活动增加，空腹血糖升高，以及低胰岛素和高血糖水平，在响应于葡萄糖load.Conclusion IUGR是不链接到3-4月龄的血压升高在这个模型中。然而，在雌性大鼠中，IUGR与成年后SNS活性增加和葡萄糖耐量受损有关。J Hypertens 1999，17：1239-1248（C）Lippincott威廉姆斯& Wilkins.
Objective Epidemiological studies suggest that intrauterine growth restriction (IUGR) due to maternal undernutrition during pregnancy represents a major risk factor for hypertension and diabetes in adult age. However, placental insufficiency, rather than maternal malnutrition, is the main cause of IUGR in the Western world. We therefore studied the relationship between birth weight and adult blood pressure and glucose tolerance in an established animal model of placental insufficiency.Design IUGR was induced by uterine artery ligation in pregnant rats and the offspring were studied at 3-4 months of age,Methods In one subgroup of animals (n = 41, birth weight range 3.2-6.6 g) blood pressure was recorded over 72 h using telemetry and hypothalamic tissue levels of noradrenaline was measured. In another subgroup (n = 30, birth weight range 3.0-6.8 g) the activity of the sympathetic nervous system (SNS) was assessed by noradrenaline isotope dilution techniques and glucose tolerance determined by an intravenous glucose load.Results Adult brood pressure was independent of birth weight Haemodynamic responses of IUGR rats to moderate sound stress was unaltered. In male rats neither SNS activity, hypothalamic noradrenaline concentrations nor glucose tolerance was associated with birth weight. In contrast, IUGR in female rats was associated with increased SNS activity, elevated fasting blood glucose as well as lower insulin and higher glucose levels in response to a glucose load.Conclusion IUGR is not linked to an elevated blood pressure at 3-4 months of age in this model. However, in female rats, IUGR is associated with increased SNS activity and impaired glucose tolerance in adult life. J Hypertens 1999, 17:1239-1248 (C) Lippincott Williams & Wilkins.