Role of Oxidative Stress in Ocular Diseases: A Balancing Act.
Role of Oxidative Stress in Ocular Diseases: A Balancing Act.
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DOI：
10.3390/metabo13020187
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发表时间：
2023-01-27
期刊：
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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Redox homeostasis is a delicate balancing act of maintaining appropriate levels of antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any disruption of this balance leads to oxidative stress, which is a key pathogenic factor in several ocular diseases. In this review, we present the current evidence for oxidative stress and mitochondrial dysfunction in conditions affecting both the anterior segment (e.g., dry eye disease, keratoconus, cataract) and posterior segment (age-related macular degeneration, proliferative vitreoretinopathy, diabetic retinopathy, glaucoma) of the human eye. We posit that further development of therapeutic interventions to promote pro-regenerative responses and maintenance of the redox balance may delay or prevent the progression of these major ocular pathologies. Continued efforts in this field will not only yield a better understanding of the molecular mechanisms underlying the pathogenesis of ocular diseases but also enable the identification of novel druggable redox targets and antioxidant therapies.
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DOI：
10.3390/antiox10010089
发表时间：
2021-01-11
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Álvarez-Barrios A;Álvarez L;García M;Artime E;Pereiro R;González-Iglesias H
通讯作者：
González-Iglesias H
DOI：
10.3390/life11050453
发表时间：
2021-05-19
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Pietras-Baczewska A;Nowomiejska K;Brzozowska A;Toro MD;Załuska W;Sztanke M;Sztanke K;Rejdak R
通讯作者：
Rejdak R
影响因子：
0.2
作者：
Ardeljan, D.;Tuo, J.;Chan, C. -C.
通讯作者：
Chan, C. -C.
影响因子：
--
作者：
Afanas'ev I
通讯作者：
Afanas'ev I
DOI：
10.1016/j.bbamcr.2009.07.001
发表时间：
2009-10
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Dhar SS;Liang HL;Wong-Riley MT
通讯作者：
Wong-Riley MT