Influence of Socioeconomic Deprivation on the Relation Between Air Pollution and β-Agonist Sales for Asthma
Influence of Socioeconomic Deprivation on the Relation Between Air Pollution and β-Agonist Sales for Asthma
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DOI：
10.1378/chest.08-1604
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发表时间：
2009-03-01
期刊：
影响因子：
9.6
通讯作者：
Bard, Denis
中科院分区：
文献类型：
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作者：
Laurent, Olivier;Pedrono, Gaelle;Bard, Denis
背景：空气污染会在暴露后数小时至数天引发哮喘发作。目前尚不清楚社会经济剥夺是否会调节这些影响。对这些相互作用的研究需要足够的统计功效，可以通过使用足够数量的观察结果或非常敏感的哮喘发作指标来获得。使用小面积的时间生态学方法，我们研究了环境空气污染和销售的短效P-受体激动剂（SABA）药物，频繁和具体的治疗控制哮喘发作的儿童和年轻人之间的短期关系，然后测试剥夺这些relationships.Methods的影响：这项研究发生在斯特拉斯堡，法国在2004年。健康保险基金提供了0至39岁患者的15，121例SABA销售数据。使用根据人口普查数据构建的指数，按小的地理区域估计了人口密度。颗粒物（空气动力学直径< 10 μ m的颗粒物[PM10]）、二氧化氮（NO2）和臭氧（O-3）的日平均环境浓度在小面积上进行了建模。水平采用调整后的病例交叉模型进行统计分析。环境中PM10、NO2和O-3浓度每增加10 μ g/m3，分别增加7.5%（95%置信区间[CI]，4 - 11.2%）、8.40%（95% CI，5 - 11.9%）和1%（95% CI，- 0.3 - 2.2%）。痴呆症没有影响这些relations.Conclusion：协会观察到的是一致的研究，专注于SABA的使用。在其他情况下进行的类似研究应能证实，与贫困缺乏互动是否是由于当地的具体条件。
Background: Air pollution triggers asthmsa attacks hours to days after exposure. It remains unclear whether socioeconomic deprivation modulates these effects. Investigation of these interactions requires adequate statistical power, obtainable by using either a sufficient number of observations or very sensitive indicators of asthma attacks. Using a small-area temporal ecologic approach, we studied the short-term relations between ambient air pollution and sales of short-acting P-agonist (SABA) drugs, a frequent and specific treatment for control of asthma attacks in children and young adults, and then tested the influence of deprivation on these relations.Methods: The study took place in Strasbourg, France in 2004. Health insurance funds provided data on 15,121 SABA sales for patients aged 0 to 39 years. Deprivation was estimated by, small geographic areas using an index constructed from census data. Daily average ambient concentrations of particulate matter (particles with an aerodynamic diameter < 10 mu m [PM10]), nitrogen dioxide (NO2),and ozone (O-3) were modeled on a small-area. level. Adjusted case-crossover models were used for statistical analysis.Results: Increased of 10 mu g/m(3) in ambient PM10, NO2, and O-3 concentrations were associated, respectively, with increases of 7.5% (95% confidence interval [CI], 4 to 11.2%), 8.40% (95% CI, 5 to 11.9%), and 1% (95% CI, - 0.3 to 2.2%) in SABA sales. Deprivation had no influence on these relations.Conclusion: The associations observed are consistent with those reported by studies focusing on SABA use. Similar studies in other settings should confirm whether the lack of interaction with deprivation is due to specific local conditions.