Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus
Ductus arteriosus ligation and alveolar growth in preterm baboons with a patent ductus arteriosus
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DOI：
10.1203/pdr.0b013e318163a8e4
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发表时间：
2008-03-01
影响因子：
3.6
通讯作者：
Clyman, Ronald I.
中科院分区：
文献类型：
--
作者：
Chang, Ling Yi;McCurnin, Donald;Clyman, Ronald I.
早产新生狒狒[妊娠125天（67%）]暴露于中等大小的动脉导管未闭（PDA）[肺与全身血流比（Qp/Qs）= 1.8]14天，与年龄匹配的胎儿（妊娠140天）相比，肺功能受损，肺泡发育和表面积停滞。 PDA 的药物闭合可减少早产对肺功能和表面积的不利影响。我们使用早产狒狒（妊娠 125 天分娩并通气 14 天）来研究手术 PDA 结扎对肺功能和肺泡表面积的影响。结扎后（生命第 6 天），结扎动物的 Qp/Qs 比率较低 [Qp/Qs（结扎，n = 10）= 1.00 +/- 0.04； （未结扎，n = 12）= 2.05 +/- 0.17；平均+/- SD]和比未结扎对照动物更高的全身血压。在术前或术后期间，各组之间的通气和氧合指数没有差异。通过数字图像分析进行肺泡表面积测量，并与妊娠 125 天（n = 6）和 140 天（n = 7）时胎儿肺部的测量结果进行比较。 PDA 结扎未能改善出生后肺泡表面积的停滞。与药物闭合 PDA 相比，手术闭合无法改善具有中度 PDA 分流的狒狒的肺功能或肺泡表面积。
Premature newborn baboons [125 d (67%) gestation], exposed to a moderate-size patent ductus arteriosus (PDA) [pulmonary-to-systemic blood-flow-ratio (Qp/Qs) = 1.8] for 14 d, have impaired pulmonary function and arrested alveolar development and surface area when compared with age matched fetuses (140 d gestation). Pharmacologic closure of the PDA reduces the detrimental effects of preterm delivery on pulmonary function and surface area. We used preterm baboons (delivered at 125 d gestation and ventilated for 14 d) to study the effects of surgical PDA ligation on pulmonary function and alveolar surface area. After ligation (on day of life 6), ligated animals had lower Qp/Qs ratios [Qp/Qs (ligated, n = 10) = 1.00 +/- 0.04; (nonligated, n = 12) = 2.05 +/- 0.17; mean +/- SD] and higher systemic blood pressures than nonligated control animals. Ventilation and oxygenation indices did not differ between the groups, during either the pre- or postoperative periods. Alveolar surface area measurements were made by digital image analysis and compared with measurements made from fetal lungs at 125 d (n = 6) and 140 d (n = 7) gestation. PDA ligation failed to improve the postnatal arrest in alveolar surface area. In contrast with pharmacologic closure of the PDA, surgical closure failed to improve either pulmonary function or alveolar surface area in baboons with a moderate PDA shunt.