Suicide transport of ricin demonstrates the presence of substance P receptors on medullary somatic and autonomic motor neurons.
Suicide transport of ricin demonstrates the presence of substance P receptors on medullary somatic and autonomic motor neurons.
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蓖麻毒素的自杀转运表明髓质体细胞和自主运动神经元上存在 P 物质受体。
DOI：
10.1016/0006-8993(85)91343-5
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Wiley,RG
中科院分区：
文献类型：
--
作者：
Helke,CJ;Charlton,CG;Wiley,RG
有毒凝集素、蓖麻毒素通过舌下神经元和迷走神经元的自杀性转运导致相关核中的运动神经元损失，并减少相同核中125 I-Bolton-Hunter标记的物质P的结合。这些数据表明，P物质受体位于舌下神经和迷走神经的髓质体细胞和节前运动神经元的细胞体上，并且自杀转运是确定细胞核内结合位点的细胞定位的有用技术。
Suicide transport of the toxic lectin, ricin, by hypoglossal and vagus neurons resulted in motor neuron loss in the associated nuclei, and reduced the binding of the125I-Bolton-Hunter labeled substance P in the same nuclei. These data show that substance P receptors are located on the cell bodies of medullary somatic and preganglionic motor neurons of the hypoglossal and vagus nerves, and that suicide transport is a useful technique to determine the cellular localization of binding sites within a nucleus.