Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal
Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal
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DOI：
10.1089/vbz.2019.2592
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发表时间：
2020-05-19
影响因子：
2.1
通讯作者：
Davoust, Bernard
中科院分区：
文献类型：
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作者：
Mangombi, Joa Brathe;Roqueplo, Cedric;Davoust, Bernard
克里米亚-刚果出血热(CCHF)是一种扁虱传播的疾病，可通过直接接触病毒体动物或人类感染。在西非，毛里塔尼亚和塞内加尔不断观察到CCHF的反复暴发。此外，人类感染的获得性和流行病学与家畜中病毒的发生和血清阳性率有关。这项研究的主要目的是提供关于塞内加尔北部地区动物中CCHF当地传播的最新信息。在采集的283份动物血清中，92份(32.5%；可信区间[CI](95%)27.1-38.3)经双抗原夹心酶联免疫吸附试验(EL ISA)鉴定出CCHF特异性抗体。马、牛、绵羊、狗、驴、山羊的CCHFV感染率分别为70.3%(45/14)、57.1%(8/14)、22.1%(30/136)、18.2%(2/11)、17.2%(5/29)、6.9%(2/29)。年龄(p<；0.0001)和性别(p<；0.05)对抗体效价有显著影响。扁头姬蜂高密度寄生。和透明线虫Hyalomma spp.被记录在马身上。在本研究中观察到塞内加尔北部地区动物中CCHFV血清阳性率很高，这表明该国北部地区长期存在这种感染，这表明有必要加强塞内加尔的CCHF监测计划。
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that can be contracted by direct contact with viremic animals or humans. In West Africa, recurrent CCHF outbreaks have been constantly observed in Mauritania and Senegal. Moreover, acquisition and epidemiology of the infection in humans are correlated with the occurrence and the seroprevalence of the virus in livestock. The main objective of this study is to provide updated information on the local spread of CCHF in animals in the northern region of Senegal. Out of a total of 283 animal sera collected, CCHF-specific antibodies were identified in 92 (32.5%; confidence interval [CI](95%) 27.1-38.3) sera by double antigen sandwich enzyme-linked immunosorbent assay (ELISA) test. The prevalence of CCHF virus (CCHFV) infection among horses, cattle, sheep, dogs, donkeys, and goats was 70.3% (45/64), 57.1% (8/14), 22.1% (30/136), 18.2% (2/11), 17.2% (5/29), and 6.9% (2/29), respectively. The antibody titers were found significantly affected by age (p < 0.0001) and gender (p < 0.05). High tick infestation by Rhipicephalus spp. and Hyalomma spp. was recorded on horses. The high seroprevalence to CCHFV among animals in the northern region of Senegal observed in this study indicates the permanent presence of the infection in the northern region of the country suggesting the need to strengthen surveillance plans for CCHF in Senegal.