PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
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DOI：
10.1126/science.1092138
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发表时间：
2004-01-30
期刊：
影响因子：
56.9
通讯作者：
Chan, AC
中科院分区：
文献类型：
--
作者：
Hasegawa, K;Martin, F;Chan, AC
蛋白质酪氨酸激酶和磷酸酶协同调节正常的免疫细胞功能。我们研究了PEST结构域富集的酪氨酸磷酸酶（PEP）在胸腺细胞发育和外周血T细胞分化过程中调节T细胞抗原受体功能的作用。虽然正常的幼稚T细胞功能保留在pep缺陷小鼠，效应/记忆T细胞表现出增强的Lck激活。反过来，这导致效应/记忆T细胞库的扩增和功能增加，这也与生发中心的自发发育和血清抗体水平升高有关。这些结果揭示了PEP在负调节T细胞发育和功能的特定方面中的核心作用。
Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain - enriched tyrosine phosphatase ( PEP) in regulating T cell antigen - receptor function during thymocyte development and peripheral T cell differentiation. Although normal naive T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.