Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation
Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation
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DOI：
10.1016/j.neurobiolaging.2017.06.016
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发表时间：
2017-11-01
影响因子：
4.2
通讯作者：
Chetelat, Gael
中科院分区：
文献类型：
--
作者：
Arenaza-Urquijo, Eider M.;Bejanin, Alexandre;Chetelat, Gael
智力丰富效应背后的大脑机制可能沿着正常衰老的阿尔茨海默病（AD）认知谱演变，并且可能包括保护机制和补偿机制。我们评估了早期智力丰富（受教育程度、年数）与平均皮质氟贝吡标准化摄取值比率之间的关联，并对总共 140 名参与者（包括认知正常的老年人、轻度认知障碍 (MCI) 和 AD 患者）进行了体素分析。高等教育与皮质氟贝丕正电子发射断层扫描 (florbetapir-PET) 摄取较低相关，特别是在正常老年人的额叶中，但在控制总体认知状态后，MCI 中额叶、颞叶和顶叶区域的摄取较高。 AD 中未发现关联。在 MCI 中，我们观察到在氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET) 摄入量较高的区域内进行教育后，氟脱氧葡萄糖正电子发射断层扫描 (FDG-PET) 摄入量有所增加，这表明存在补偿性增加。早期智力丰富可能与老年痴呆症发作之前对淀粉样蛋白 β (Ab) 沉积的保护和补偿有关。先前的研究对于智力富集变量对抗体沉积的影响一直存在争议。目前的研究结果呼吁采取旨在评估跨疾病阶段的恢复机制的方法。 (C) 2017 Elsevier Inc. 保留所有权利。
The brain mechanisms underlying the effect of intellectual enrichment may evolve along the normal aging Alzheimer's disease (AD) cognitive spectrum and may include both protective and compensatory mechanisms. We assessed the association between early intellectual enrichment ( education, years) and average cortical florbetapir standardized uptake value ratio as well as performed voxel-wise analyses in a total of 140 participants, including cognitively normal older adults, mild cognitive impairment (MCI), and AD patients. Higher education was associated with lower cortical florbetapir positron emission tomography (florbetapir-PET) uptake, notably in the frontal lobe in normal older adults, but with higher uptake in frontal, temporal, and parietal regions in MCI after controlling for global cognitive status. No association was found in AD. In MCI, we observed an increased fluorodeoxyglucose positron emission tomography (FDG-PET) uptake with education within the regions of higher florbetapir-PET uptake, suggesting a compensatory increase. Early intellectual enrichment may be associated with protection and compensation for amyloid beta (Ab) deposition later in life, before the onset of dementia. Previous investigations have been controversial as regard to the effects of intellectual enrichment variables on Ab deposition; the present findings call for approaches aiming to evaluate mechanisms of resilience across disease stages. (C) 2017 Elsevier Inc. All rights reserved.