Geographic Variation in Obesity at the State Level in the All of Us Research Program.
Geographic Variation in Obesity at the State Level in the All of Us Research Program.
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DOI：
10.5888/pcd18.210094
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发表时间：
2021-12-23
影响因子：
5.5
通讯作者：
Karlson EW
中科院分区：
文献类型：
--
作者：
Clark CR;Chandler PD;Zhou G;Noel N;Achilike C;Mendez L;O'Connor GT;Smoller JW;Weiss ST;Murphy SN;Ommerborn MJ;Karnes JH;Klimentidis YC;Jordan CD;Hiatt RA;Ramirez AH;Loperena R;Mayo K;Cohn E;Ohno-Machado L;Boerwinkle E;Cicek M;Schully SD;Mockrin S;Gebo KA;Karlson EW
国家肥胖预防战略可能受益于人口健康研究中涉及不同参与者的精确健康方法。我们使用了来自美国国立卫生研究院所有人研究计划(我们所有人)研究人员工作台的队列数据来估计人群水平的肥胖流行率。为了估计州一级的肥胖流行率，我们使用了在我们所有注册访问期间进行的身体测量数据和参与者电子健康记录(EHR)的数据(如果有)。按州计算并绘制了两类身体质量指数(BMI)(公斤/平方米)的患病率估计值：肥胖(BMI>；30)和严重肥胖(BMI>；35)。我们计算并绘制了各州的流行率图，排除了所有参与者少于100人的州。来自33个州的244,504名我们所有参与者获得了有关身高和体重的数据，其中88,840名参与者获得了相应的电子健康记录数据。体重指数的中位数和IQR分别为28.4(24.4-33.7)和28.5(24.5-33.6)。基于身体测量数据的总体肥胖率为41.5%(95%CI，41.3%-41.7%)；严重肥胖率为20.7%(95%CI，20.6-20.9)，不同州的地理差异很大。来自我们所有参与者人数较多的州的患病率估计与基于全国人口的估计更接近，而不是参与者较少的州。我们所有的参与者都有很高的肥胖率，州一级的地理差异反映了全国的趋势。我们所有参与者的多样性可能会支持未来在不同人群中进行肥胖预防和治疗的研究。
National obesity prevention strategies may benefit from precision health approaches involving diverse participants in population health studies. We used cohort data from the National Institutes of Health All of Us Research Program (All of Us) Researcher Workbench to estimate population-level obesity prevalence. To estimate state-level obesity prevalence we used data from physical measurements made during All of Us enrollment visits and data from participant electronic health records (EHRs) where available. Prevalence estimates were calculated and mapped by state for 2 categories of body mass index (BMI) (kg/m2): obesity (BMI >30) and severe obesity (BMI >35). We calculated and mapped prevalence by state, excluding states with fewer than 100 All of Us participants. Data on height and weight were available for 244,504 All of Us participants from 33 states, and corresponding EHR data were available for 88,840 of these participants. The median and IQR of BMI taken from physical measurements data was 28.4 (24.4– 33.7) and 28.5 (24.5–33.6) from EHR data, where available. Overall obesity prevalence based on physical measurements data was 41.5% (95% CI, 41.3%–41.7%); prevalence of severe obesity was 20.7% (95% CI, 20.6–20.9), with large geographic variations observed across states. Prevalence estimates from states with greater numbers of All of Us participants were more similar to national population-based estimates than states with fewer participants. All of Us participants had a high prevalence of obesity, with state-level geographic variation mirroring national trends. The diversity among All of Us participants may support future investigations on obesity prevention and treatment in diverse populations.