Computational biology of the heart: from structure to function.
Computational biology of the heart: from structure to function.
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DOI：
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发表时间：
1998
影响因子：
3.8
通讯作者：
A. McCulloch;J. Bassingthwaighte;P. Hunter;D. Noble
中科院分区：
文献类型：
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作者：
A. McCulloch;J. Bassingthwaighte;P. Hunter;D. Noble
在过去的二三十年里，生物学研究以其还原模式取得了惊人的成功。分子机制，如离子通道和转运体的门控、药物与受体的相互作用、蛋白质表达的控制和调控，这些机制在20世纪60年代和70年代的细胞生物物理学中只能被视为‘黑匣子’，现在不仅从详细的分子序列和结构方面揭示出来，而且在许多情况下与它们的遗传编码有关。随着人类基因组计划的终点已经近在眼前，人们的兴奋似乎很快就会结束，留给我们的继任者继续填写细节和扩大应用范围的长期任务。然而，这将是对分子生物学方法的性质和下一个主要挑战必须是什么的深刻误解。
The last two or three decades have been a spectacular success for biological research in its reductive mode. Molecular mechanisms, such as the gating of ionic channels and transporters, drug-receptor interactions, control of protein expression and regulation, that could only be treated as ‘black boxes’ by the cell biophysics of the 1960s and 1970s have now been revealed not only in terms of detailed molecular sequences and structures but also, in many cases, in relation to their genetic coding. With the end-point of the Human Genome Project already in sight, it might seem that the excitement will soon be over, leaving our successors to continue the long task of filling in the details and widening the range of applications. That would, however, be a profound misunderstanding both of the nature of the molecular biological approach and of what the next major challenge must be.