Prospective analysis of traits related to 6-year change in sodium-lithium countertransport. Gubbio Population Study Research Group.
Prospective analysis of traits related to 6-year change in sodium-lithium countertransport. Gubbio Population Study Research Group.
复制标题
钠-锂反转运 6 年变化相关性状的前瞻性分析。
DOI：
10.1161/01.hyp.33.3.887
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Stamler,J
中科院分区：
文献类型：
--
作者：
Cirillo,M;Laurenzi,M;Panarelli,W;Trevisan,M;Stamler,J
- 红细胞中的钠-锂反向转运（Na-Li CT）活性在横截面和纵向上与血压和高血压相关。生活方式和代谢因素与这种钠转运蛋白的横截面相关。本研究的目的是进行前瞻性分析6年钠锂CT的变化和性状的相关钠锂CT的变化。在古比奥人口研究的2183名参与者中，（972名男性和1211名女性;基线年龄，18至74岁），分析在基线和6年随访时收集的以下数据：钠-锂CT、性别、年龄、体重指数（BMI）、血压、抗高血压治疗、饮酒、吸烟习惯、尿钠/钾比值。以及血浆胆固醇、葡萄糖、尿酸、钠、钾和甘油三酯（仅在随访时测量）。6年变化定义为随访值减去基线值。随访时，两种性别的钠锂CT均高于基线（P<0.001）。基线Na-Li CT;基线值和BMI变化值以及与Na-Li CT相关的酒精摄入量、血浆钾和血浆葡萄糖的变化值显著且独立于其他变量的对照。随访血浆甘油三酯水平也与Na-Li CT变化独立相关。BMI、酒精摄入量、血糖和甘油三酯水平的相关系数为正，基线Na-Li CT和血浆钾水平的相关系数为负。其他变量的基线值和变化值与Na-Li CT变化无显著相关性。总之，在前瞻性分析中，BMI、酒精摄入量、血糖和血脂与Na-Li CT变化直接相关;基线Na-Li CT和血浆钾水平呈负相关。这些数据支持生活方式和相关代谢因素影响钠锂CT的概念。
—Sodium-lithium countertransport (Na-Li CT) activity in red blood cells relates cross-sectionally and longitudinally to blood pressure and hypertension. Lifestyle and metabolic factors relate cross-sectionally to this sodium transporter. The aim of this study was to conduct a prospective analysis of 6-year Na-Li CT change and of traits related to Na-Li CT change. In 2183 participants in the Gubbio Population Study (972 men and 1211 women; baseline ages, 18 to 74 years), the following data collected at baseline and 6-year follow-up were analyzed: Na-Li CT; gender; age; body mass index (BMI); blood pressure; antihypertensive treatment; alcohol intake; smoking habits; urinary sodium-to-potassium ratio; and plasma cholesterol, glucose, uric acid, sodium, potassium, and triglycerides (measured only at follow-up). Six-year changes were defined as follow-up minus baseline values. Na-Li CT was higher at follow-up than at baseline in both genders (P<0.001). Baseline Na-Li CT; baseline and change values of BMI; and change values of alcohol intake, plasma potassium, and plasma glucose related to Na-Li CT change significantly and independently with control for other variables. Follow-up plasma triglyceride levels also related independently to Na-Li CT change. Coefficients were positive for BMI, alcohol intake, and plasma glucose and triglyceride levels and were negative for baseline Na-Li CT and plasma potassium levels. Baseline and change values of other variables did not relate significantly to Na-Li CT change. In conclusion, in prospective analyses, BMI, alcohol intake, plasma glucose, and lipids were directly related to Na-Li CT change; baseline Na-Li CT and plasma potassium levels were inversely related. The data support the concept that lifestyle and related metabolic factors influence Na-Li CT.