Estimation of bone-mineral density from OCT images
Estimation of bone-mineral density from OCT images
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从 OCT 图像估计骨矿物质密度
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
D. Attenburrow
中科院分区：
文献类型：
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作者：
N. Ugryumova;S. Matcher;D. Attenburrow
以前，我们已经证明了积分球技术的骨密度（BMD）和光学散射系数（μs）之间的一个有用的相关性。我们使用OCT来研究这种关系，以期评估其作为体内BMD测量的可行性。我们使用在1.3微米下操作的OCT系统对各种骨样本进行成像，并在不同方向上进行成像。为了研究OCT测量的准确性，我们收集了沿骨样本轴沿着不同部位拍摄的平均图像。测量系数的微小变化（约3%）证明了使用OCT技术进行此类测量的可能性。测量骨与骨膜和无骨膜，基本上表现出相同的光学特性。垂直和平行于胶原纤维的主方向施加入射光束，得到约40%的散射系数差异，这证实了我们先前关于骨物质各向异性的建议。收集不同脱矿时间的骨样本图像。他们允许以下变化的钙分布在皮质骨的一部分，随着时间的增加，酸活动。
Previously we have demonstrated by an integrating-sphere technique a useful correlation between bone mineral density (BMD) and the optical scattering coefficient (μs). We have used OCT to study this relationship, with a view to assessing its viability as an in vivo measure of BMD. We used an OCT system operating at 1.3 microns to image various bone samples and to make images in different directions. To investigate the accuracy of OCT measurements we collected averaged images taken at different sites along the shaft of a bone sample. A small (about 3%) variation in measured coefficients, justifies the possibility of using the OCT technique for this kind of measurement. Measurements of bone both with and without periosteum, showed essentially the same optical properties. Applying the incident light beam perpendicular and parallel to the main direction of the collagen fibers gave differences in scattering coefficient of about 40% that confirms our previous suggestion about anisotropy of bone matter. Images of bone samples for different demineralisation time were collected. They allowed following changes in calcium distribution in cortical part of bone with the increasing time of acid activity.