Trypanosoma cruzi infection induced changes in the innervation, structure and function of the murine bladder
Trypanosoma cruzi infection induced changes in the innervation, structure and function of the murine bladder
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DOI：
10.1097/01.ju.0000154170.87947.b8
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发表时间：
2005-05-01
影响因子：
6.6
通讯作者：
Christ, GJ
中科院分区：
文献类型：
--
作者：
Boczko, J;Tar, M;Christ, GJ
目的：慢性恰加斯病的下尿路受累尚未引起足够的重视。因此，我们研究了克氏锥虫感染小鼠膀胱的病理和功能变化。材料和方法：用克氏锥虫巴西株的5×10(4)克氏锥虫鞭毛虫感染CD1小鼠。在感染后第100天，通过病理评估、磁共振成像和膀胱计量学研究来检测膀胱的结构和功能。结果：与对照组相比，感染组小鼠的膀胱重量增加，体积增大，肿胀变形，脆性变薄。磁共振成像证实了这些观察结果。观察炎症、纤维化和神经节炎的变化。膀胱计量学研究显示，感染小鼠的基线、阈值和排尿压力增加。在感染的小鼠中也发现了膀胱过度活动和膀胱顺应性下降。感染和未感染的小鼠在膀胱容量、尿量和残余尿量方面没有明显差异。结论：膀胱异常可能是克氏毛滴虫感染的一种更常见的临床后遗症。
Purpose: The involvement of the lower urinary tract in chronic Chagas' disease has received little attention. Therefore, we investigated pathology and functional alterations in the bladder of Trypanosoma cruzi infected mice.Materials and Methods: CD1 mice were infected with 5 x 10(4) T. cruzi trypomastigotes of the Brazil strain of T. cruzi. At day 100 after infection bladder structure and function were examined by pathological evaluation, magnetic resonance imaging and cystometric studies.Results: The bladder in infected mice weighed more and were large, dilated, deformed, friable and thin walled compared with control mice. Magnetic resonance imaging confirmed these observations. Inflammation, fibrosis and ganglionitis was observed. Cystometric studies revealed that baseline, threshold and micturition pressures were increased in infected mice. Bladder overactivity and decreased bladder compliance were also noted in infected mice. There were no detectable differences in bladder capacity, micturition volume or residual volume between infected and uninfected mice.Conclusions: Bladder abnormalities may be a more common clinical sequelae of T. cruzi infection than previously appreciated.