Long non-coding RNA UC001kfo promotes hepatocellular carcinoma proliferation and metastasis by targeting a-SMA
Long non-coding RNA UC001kfo promotes hepatocellular carcinoma proliferation and metastasis by targeting a-SMA
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长链非编码RNA UC001kfo通过靶向a-SMA促进肝细胞癌增殖和转移
DOI：
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发表时间：
2017
影响因子：
7.5
通讯作者：
Yanfeng Pan
中科院分区：
文献类型：
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作者：
Yanfeng Pan
一些长链非编码rna （lncrna）已经被研究并发现与行为和行为相关。肝细胞癌的预后；具体来说，我们发现lncRNA UC001kfo是不同的。与正常肝组织相比，lncRNA微阵列在HCC组织中表达，但其在癌症中的功能作用。包括肝细胞癌，尚未阐明。本研究发现UC001kfo表达上调。在肝癌组织和细胞系中分别与肿瘤邻近组织和正常肝细胞进行比较。在。此外，高UC001kfo水平与HCC大血管侵袭和TNM分期相关。具体来说，UC001kfo高表达的患者表现出明显较低的总生存率和无进展。存活率。此外，单因素和多因素COX回归分析确定了TNM阶段和。UC001kfo高表达是HCC患者预后不良的危险因素。此外，UC001kfo验证推广。体外和体内研究肝癌细胞的增殖、转移和上皮间质转化（EMT）。机制上，α-SMA被认为是UC001kfo介导HCC转移的潜在靶基因。在。结论UC001kfo通过靶向α-SMA促进HCC增殖和转移，UC001kfo可能具有潜在的作用。作为肝癌的预后指标和治疗靶点。
Several long non-coding RNAs (lncRNAs) have been investigated and found to be correlated with the behaviours and.prognosis of hepatocellular carcinoma (HCC); Specifically, we revealed that the lncRNA UC001kfo was differentially.expressed in HCC tissues compared with normal liver tissues using lncRNA microarrays, but its functional role in cancers,.including HCC, has not yet been elucidated. The present study found that the expression of UC001kfo was upregulated.in HCC tissues and cell lines in comparison with tumour-adjacent tissues and normal hepatocytes, respectively. In.addition, a high UC001kfo level was determined to be correlated with macro-vascular invasion and TNM stage of HCC..Specifically, patients with high UC001kfo expression displayed a significantly lower overall survival rate and progression-free.survival rate. Moreover, both univariate and multivariate COX regression analyses identified TNM stage and.high UC001kfo expression as risk factors for poor prognosis in HCC patients. In addition, UC001kfo was verified to promote.the proliferation, metastasis and epithelial-mesenchymal transition (EMT) in HCC cells in both in vitro and in vivo.assays. Mechanistically, α-SMA was indicated as a potential target gene of UC001kfo in mediating HCC metastasis. In.conclusion, UC001kfo promotes HCC proliferation and metastasis by targeting α-SMA, and UC001kfo may potentially.serve as a prognostic marker and a therapeutic target for treatment of HCC..