[Pharmacokinetic, bacteriological and clinical studies on sulbactam/ampicillin in pediatric field].
[Pharmacokinetic, bacteriological and clinical studies on sulbactam/ampicillin in pediatric field].
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舒巴坦/氨苄西林在儿科领域的药代动力学、细菌学及临床研究[J].
DOI：
10.11553/antibiotics1968b.42.639
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
K. Kuno
中科院分区：
文献类型：
--
作者：
Y. Nakao;H. Kimura;K. Miura;Y. Miyajima;H. Ishikawa;F. Hayakawa;K. Kuno
对舒巴坦/氨苄西林（SBT/ABPC）（1：2组合比例）在儿科感染中的应用进行了临床试验。结果如下：1.静脉注射SBT/ABPC后，血清中SBT和ABPC的平均半衰期分别约为1.05和0.90小时。2.静脉注射SBT/ABPC后6 h尿中SBT和ABPC的平均排泄率分别为71.2%和62.2%。3.对23例小儿感染性疾病患者进行了SBT/ABPC治疗，其中肺炎17例，扁桃体炎3例，尿路感染2例，颈部淋巴结炎1例。总有效率为95.7%。特别是，2例由高产β-内酰胺酶大肠埃希菌引起的尿路感染通过SBT/ABPC治疗得到改善。4.除2例轻度腹泻外，未观察到不良反应。异常实验室检查值包括4例血小板增多，1例GOT和GPT轻微升高，但均为一过性。
Clinical trials were carried out on the use of sulbactam/ampicillin (SBT/ABPC) (combination rate of 1:2) in pediatric infections. Results were as follows: 1. The mean half-lives of SBT and ABPC in the serum following intravenous injection of SBT/ABPC were about 1.05 and 0.90 hours, respectively. 2. The mean urinary excretions of SBT and ABPC in 6 hours after intravenous injection of SBT/ABPC were 71.2% and 62.2%, respectively. 3. SBT/ABPC was administered to 23 pediatric patients with various infections: 17 patients with pneumonia, 3 with tonsillitis, 2 with urinary tract infection and 1 with cervical lymphadenitis. The overall efficacy rate was 95.7%. In particular, 2 urinary tract infections caused by highly beta-lactamase producing Escherichia coli were improved by the treatment with SBT/ABPC. 4. No adverse reactions were observed except 2 cases of mild diarrhea. Abnormal laboratory test values included thrombocytosis in 4 and slight elevation of GOT and GPT in 1, but they were transient.