Supramolecular Micelles Constructed by Crown Ether-Based Molecular Recognition
Supramolecular Micelles Constructed by Crown Ether-Based Molecular Recognition
复制标题
基于冠醚的分子识别构建超分子胶束
DOI：
10.1021/ma301162s
复制
发表时间：
2012-08-28
期刊：
影响因子：
5.5
通讯作者：
Huang, Feihe
中科院分区：
文献类型：
--
作者：
Ji, Xiaofan;Li, Jinying;Huang, Feihe
合成了一种新型的基于冠醚分子识别的两亲性聚合物，并证明了其在水中自组装成核壳型超分子胶束。通过改变pH值，可以实现组装结构与非组装结构之间的可逆转变，从而实现小分子的控制释放。通过电导率、透射电子显微镜（TEM）、动态激光光散射（DLS）和荧光滴定等技术对超分子胶束进行了表征。TEM照片显示暗灰色的球形聚集体，胶束的平均尺寸为50 nm的直径和分散的大小，与DLS的结果很好地一致。通过加入酸（盐酸水溶液），减弱了主客体相互作用，导致超分子胶束的解体，实现了疏水分子从胶束中的释放。
A novel supramolecular amphiphilic polymer constructed by crown ether-based molecular recognition has been fabricated and demonstrated to self-assemble into core-shell supramolecular micelles in water. The reversible transition between assembled and disassembled structures can be achieved by changing the pH. This transition was used to realize the controlled release of small molecules. The supramolecular micelle was characterized by various techniques including conductivity, transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and fluorescence titration. TEM images showed dark gray spherical aggregates, and the mean size of the micelles was 50 nm in diameter and of uniformly dispersed size, in good agreement with the DLS results. The release of hydrophobic molecules from the micelles was realized by adding acid (aqueous HCl), weakening the host-guest interactions and leading to disassembly of the supramolecular micelles.